Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia

被引：71
|
作者：
Matosin, Natalie [1 ,2 ]
Newell, Kelly A. [1 ,2 ]
机构：
[1] Univ Wollongong, Sch Hlth Sci, Ctr Translat Neurosci, Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia
[2] Schizophrenia Res Inst, Sydney, NSW 2010, Australia
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2013年 / 37卷 / 03期
关键词：
mGluR5; mGlu5; Metabotropic glutamate receptor 5; Schizophrenia; NMDA receptor; Positive allosteric modulator; PAM; Antipsychotic; POSITIVE ALLOSTERIC MODULATOR; METHYL-D-ASPARTATE; LONG-TERM POTENTIATION; MESSENGER-RNA EXPRESSION; AMINO-ACID TRANSPORTER-2; RAT BEHAVIORAL-MODELS; IN-VIVO ACTIVITY; NMDA-RECEPTOR; PREFRONTAL CORTEX; PREPULSE INHIBITION;
D O I：
10.1016/j.neubiorev.2012.12.005
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Metabotropic glutamate receptor 5 (mGluR5) potentiates the NMDA receptor (NMDAR) in brain regions implicated in schizophrenia, making it a viable therapeutic target for the treatment of this disorder. mGluR5 positive allosteric modulators may represent a valuable novel strategy for schizophrenia treatment, given the favourable profile of effects in preclinical paradigms. However it remains unclear whether mGluR5 also plays a causal or epiphenomenal role in NMDAR dysfunction in schizophrenia. Animal and cellular data suggest involvement of mGluR5, whilst post-mortem human studies remain inconclusive. This review will explore the molecular, animal and human data to support and refute the involvement of mGluR5 in the pathology of schizophrenia. Furthermore, this review will discuss the potential of mGluR5 modulators in the therapy of schizophrenia as well as aspects of mGluR5 that require further characterisation. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：256 / 268
页数：13
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