The overexpression of PXN promotes tumor progression and leads to radioresistance in cervical cancer

被引：22
|
作者：
Liu, Qiuli [1 ]
Wang, Jing [2 ]
Tang, Mei [1 ]
Chen, Ling [1 ]
Qi, Xiaowei [3 ]
Li, Juan [4 ]
Yu, Jinjin [1 ]
Qiu, Haifeng [5 ]
Wang, Yuan [1 ]
机构：
[1] Jiangnan Univ, Affiliated Hosp, Dept Obstet & Gynecol, Wuxi 214062, Peoples R China
[2] Qingdao Univ, Yantai Yuhuangding Hosp, Med Coll, Dept Obstet & Gynecol, Yantai 264000, Peoples R China
[3] Jiangnan Univ, Affiliated Hosp, Dept Pathol, Wuxi 214062, Peoples R China
[4] Wuxi Hosp Maternal & Child Hlth Care, Dept Obstet & Gynecol, Wuxi 214062, Peoples R China
[5] Zhengzhou Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Zhengzhou 450000, Henan, Peoples R China
来源：
FUTURE ONCOLOGY | 2018年 / 14卷 / 03期
关键词：
apoptosis; cervical cancer; paxillin; prognosis; proliferation; radiosensitivity; CELL LUNG-CANCER; PREDICTS SURVIVAL; GENE-EXPRESSION; PAXILLIN; INVASION; PHOSPHORYLATION; MICRORNA-218; IDENTIFICATION; STABILIZATION; METASTASIS;
D O I：
10.2217/fon-2017-0474
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: We aim to investigate the functions of PXN in cervical cancer. Materials & methods: PXN protein was investigated by immunohistochemistry in a panel of cervical cancer. A series of in vitro and in vivo assays were used to explore the efficacy of PXN. Results: PXN was significantly upregulated in cervical cancer, which associated with tumor stage, poor differentiation, lymphovascular space invasion and lymphatic metastasis. Knockdown of PXN notably impaired cellular growth and colony formation by suppressing Bcl-2 and inducing marked apoptosis. Moreover, PXN led to resistance to radiation, and downregulation of PXN resensitized C33A cells to radiation. Conclusion: PXN was frequently upregulated and acted as an oncogene via regulating Bcl-2 in cervical cancer, which supports PXN as a potent therapeutic target.
引用
收藏
页码：241 / 253
页数：13
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