The overexpression of PXN promotes tumor progression and leads to radioresistance in cervical cancer

被引：22
|
作者：
Liu, Qiuli [1 ]
Wang, Jing [2 ]
Tang, Mei [1 ]
Chen, Ling [1 ]
Qi, Xiaowei [3 ]
Li, Juan [4 ]
Yu, Jinjin [1 ]
Qiu, Haifeng [5 ]
Wang, Yuan [1 ]
机构：
[1] Jiangnan Univ, Affiliated Hosp, Dept Obstet & Gynecol, Wuxi 214062, Peoples R China
[2] Qingdao Univ, Yantai Yuhuangding Hosp, Med Coll, Dept Obstet & Gynecol, Yantai 264000, Peoples R China
[3] Jiangnan Univ, Affiliated Hosp, Dept Pathol, Wuxi 214062, Peoples R China
[4] Wuxi Hosp Maternal & Child Hlth Care, Dept Obstet & Gynecol, Wuxi 214062, Peoples R China
[5] Zhengzhou Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Zhengzhou 450000, Henan, Peoples R China
来源：
FUTURE ONCOLOGY | 2018年 / 14卷 / 03期
关键词：
apoptosis; cervical cancer; paxillin; prognosis; proliferation; radiosensitivity; CELL LUNG-CANCER; PREDICTS SURVIVAL; GENE-EXPRESSION; PAXILLIN; INVASION; PHOSPHORYLATION; MICRORNA-218; IDENTIFICATION; STABILIZATION; METASTASIS;
D O I：
10.2217/fon-2017-0474
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: We aim to investigate the functions of PXN in cervical cancer. Materials & methods: PXN protein was investigated by immunohistochemistry in a panel of cervical cancer. A series of in vitro and in vivo assays were used to explore the efficacy of PXN. Results: PXN was significantly upregulated in cervical cancer, which associated with tumor stage, poor differentiation, lymphovascular space invasion and lymphatic metastasis. Knockdown of PXN notably impaired cellular growth and colony formation by suppressing Bcl-2 and inducing marked apoptosis. Moreover, PXN led to resistance to radiation, and downregulation of PXN resensitized C33A cells to radiation. Conclusion: PXN was frequently upregulated and acted as an oncogene via regulating Bcl-2 in cervical cancer, which supports PXN as a potent therapeutic target.
引用
收藏
页码：241 / 253
页数：13
相关论文
共 50 条
  • [21] Overexpression of PCDH7 and SET Leads to Aberrant ERK and AKT Signaling and Promotes Prostate Cancer Progression
    Shishodia, Gauri
    Koul, Sweaty
    Koul, Hari
    FASEB JOURNAL, 2019, 33
  • [22] FOXP1 OVEREXPRESSION IS ASSOCIATED WITH TUMOR PROGRESSION AND POOR PROGNOSIS IN PATIENTS WITH CERVICAL CANCER
    Cho, H.
    Chay, D. B.
    Kim, H. J.
    Lee, J. Y.
    Sohn, G. S.
    Kim, Y. T.
    Kim, J. H.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2014, 24 (09) : 575 - 575
  • [23] Epigenetic silencing of miR-193a leads to tumor progression through overexpression of YWHAZ in gastric cancer
    Low, Jie T.
    Wei, Kuo L.
    Chou, Jian L.
    Chen, Yin C.
    Lin, Guan L.
    Liu, Jing L.
    Chang, Te S.
    Chen, Wei M.
    Yan, Pearlly S.
    Chuang, Yu M.
    Lin, Jora M.
    Wu, Shu F.
    Li, Chin
    Wu, Cheng S.
    Chan, Michael W.
    CANCER SCIENCE, 2022, 113 : 1667 - 1667
  • [24] Long noncoding RNA PXN-AS1-L promotes non-small cell lung cancer progression via regulating PXN
    Zhang, Zhifa
    Peng, Zhaohui
    Cao, Junying
    Wang, Jiaqi
    Hao, Yongyu
    Song, Kai
    Wang, Yan
    Hu, Wei
    Zhang, Xuesong
    CANCER CELL INTERNATIONAL, 2019, 19 (1)
  • [25] Long noncoding RNA PXN-AS1-L promotes non-small cell lung cancer progression via regulating PXN
    Zhifa Zhang
    Zhaohui Peng
    Junying Cao
    Jiaqi Wang
    Yongyu Hao
    Kai Song
    Yan Wang
    Wei Hu
    Xuesong Zhang
    Cancer Cell International, 19
  • [26] β-catenin nuclear translocation induced by HIF-1α overexpression leads to the radioresistance of prostate cancer
    Luo, Yong
    Li, Mingchuan
    Zuo, Xuemei
    Basourakos, Spyridon P.
    Zhang, Jiao
    Zhao, Jiahui
    Han, Yili
    Lin, Yunhua
    Wang, Yongxing
    Jiang, Yongguang
    Lan, Ling
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2018, 52 (06) : 1827 - 1840
  • [27] Overexpression of CLEC3A promotes tumor progression and poor prognosis in breast invasive ductal cancer
    Ni, Jun
    Peng, Yun
    Yang, Fu-Lan
    Xi, Xun
    Huang, Xing-Wei
    He, Chun
    ONCOTARGETS AND THERAPY, 2018, 11 : 3303 - 3312
  • [28] The overexpression of Rab9 promotes tumor progression regulated by XBP1 in breast cancer
    Liu, Yansong
    Wang, Xin
    Zhang, Zhonghua
    Xiao, Bin
    An, Baoming
    Zhang, JUn
    ONCOTARGETS AND THERAPY, 2019, 12 : 1815 - 1824
  • [29] Overexpression of NOX4 predicts poor prognosis and promotes tumor progression in human colorectal cancer
    Lin, Xiao-Lu
    Yang, Li
    Fu, Seng-Wang
    Lin, Wen-Feng
    Gao, Yun-Jie
    Chen, Hao-Yan
    Ge, Zhi-Zheng
    ONCOTARGET, 2017, 8 (20) : 33586 - 33600
  • [30] Overexpression of paxillin induced by miR-137 suppression promotes tumor progression and metastasis in colorectal cancer
    Chen, Dong-Liang
    Wang, De-Shen
    Wu, Wen-Jing
    Zeng, Zhao-Lei
    Luo, Hui-Yan
    Qiu, Miao-Zhen
    Ren, Chao
    Zhang, Dong-Sheng
    Wang, Zhi-Qiang
    Wang, Feng-Hua
    Li, Yu-Hong
    Kang, Tie-Bang
    Xu, Rui-Hua
    CARCINOGENESIS, 2013, 34 (04) : 803 - 811
12345