Is Hydrogen Cyanide a Marker of Burkholderia cepacia Complex?

被引：12

作者：

Gilchrist, Francis J. ^{[1
,2
,4
]}

Sims, Hayley ^{[3
]}

Alcock, Alice ^{[3
]}

Jones, Andrew M. ^{[2
]}

Bright-Thomas, Rowland J. ^{[2
]}

Smith, David ^{[4
]}

Spanel, Patrik ^{[4
,5
]}

Webb, A. Kevin ^{[2
]}

Lenney, Warren ^{[1
,4
]}

机构：

[1] Univ Hosp North Staffordshire, Acad Dept Child Hlth, Stoke On Trent, Staffs, England

[2] Wythenshawe Hosp, Manchester Adult Cyst Fibrosis Ctr, Manchester M23 9LT, Lancs, England

[3] Univ Hosp North Staffordshire, Dept Microbiol, Stoke On Trent, Staffs, England

[4] Keele Univ, Inst Sci & Technol Med, Guy Hilton Res Ctr, Stoke On Trent, Staffs, England

[5] Acad Sci Czech Republic, J Heyrovsky Inst Phys Chem, Prague, Czech Republic

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2013年 / 51卷 / 11期

关键词：

PSEUDOMONAS-AERUGINOSA;

D O I：

10.1128/JCM.02157-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Biofilm cultures of Burkholderia cepacia complex (BCC) infection have been found to generate the nonvolatile cyanide ion. We investigated if gaseous hydrogen cyanide (HCN) was a marker of BCC infection. Selected ion flow tube mass spectrometry analysis showed HCN was not elevated in the headspace of planktonic or biofilm cultures or in the exhaled breath of adult cystic fibrosis patients with chronic BCC infection. HCN is therefore not an in vitro or in vivo marker of BCC.

引用

页码：3849 / 3851

页数：3

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