The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

被引：12
|
作者：
Garavito, Giovanny [1 ]
Bertani, Stephane [2 ,3 ]
Quiliano, Miguel [4 ]
Valentin, Alexis [2 ]
Aldana, Ignacio [4 ]
Deharo, Eric [2 ,5 ]
机构：
[1] Univ Nacl Colombia, Dept Farm, Fac Ciencias, Bogota, Colombia
[2] Univ Toulouse 3, Univ Toulouse, Pharma Dev UMR 152, Fac Pharm, F-31062 Toulouse, France
[3] Inst Rech Dev, Pharma Dev UMR 152, Lima, Peru
[4] Univ Navarra, Neglected Dis Sect, Drug R&D Unit, Ctr Appl Pharmacobiol Res, E-31080 Pamplona, Spain
[5] Inst Rech Dev, Pharma Dev UMR 152, Fac Pharm, Toulouse, France
来源：
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2012年 / 107卷 / 06期
关键词：
antimalarials; methylene blue; drug combination; PLASMODIUM-FALCIPARUM; GLUTATHIONE-REDUCTASE; VITRO ASSESSMENT; COMBINATION; MALARIA; DRUG; ERYTHROCYTES; RESISTANCE; SAFETY;
D O I：
10.1590/S0074-02762012000600019
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.
引用
收藏
页码：820 / 823
页数：4
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