The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

被引：12

作者：

Garavito, Giovanny ^{[1
]}

Bertani, Stephane ^{[2
,3
]}

Quiliano, Miguel ^{[4
]}

Valentin, Alexis ^{[2
]}

Aldana, Ignacio ^{[4
]}

Deharo, Eric ^{[2
,5
]}

机构：

[1] Univ Nacl Colombia, Dept Farm, Fac Ciencias, Bogota, Colombia

[2] Univ Toulouse 3, Univ Toulouse, Pharma Dev UMR 152, Fac Pharm, F-31062 Toulouse, France

[3] Inst Rech Dev, Pharma Dev UMR 152, Lima, Peru

[4] Univ Navarra, Neglected Dis Sect, Drug R&D Unit, Ctr Appl Pharmacobiol Res, E-31080 Pamplona, Spain

[5] Inst Rech Dev, Pharma Dev UMR 152, Fac Pharm, Toulouse, France

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2012年 / 107卷 / 06期

关键词：

antimalarials; methylene blue; drug combination; PLASMODIUM-FALCIPARUM; GLUTATHIONE-REDUCTASE; VITRO ASSESSMENT; COMBINATION; MALARIA; DRUG; ERYTHROCYTES; RESISTANCE; SAFETY;

D O I：

10.1590/S0074-02762012000600019

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

引用

页码：820 / 823

页数：4

共 50 条

[21] Enhancement of the antimalarial effect of chloroquine by chloropheniramine in vivo
Sowunmi, A
Oduola, AMJ
Ogundahunsi, OAT
Salako, LA
TROPICAL MEDICINE & INTERNATIONAL HEALTH, 1998, 3 (03) : 177 - 183
[22] THE PHARMACOLOGICAL BASIS FOR THE PROLONGED ANTIMALARIAL ACTIVITY OF PYRIMETHAMINE
SMITH, CC
IHRIG, J
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1957, 6 (01): : 50 - 57
[23] In vitro and in vivo antimalarial activity of ferrochloroquine, a ferrocenyl analogue of chloroquine against chloroquine-resistant malaria parasites
L. Delhaes
H. Abessolo
C. Biot
L. Berry
P. Delcourt
L. Maciejewski
J. Brocard
D. Camus
D. Dive
Parasitology Research, 2001, 87 : 239 - 244
[24] In vitro and in vivo antimalarial activity of ferrochloroquine, a ferrocenyl analogue of chloroquine against chloroquine-resistant malaria parasites
Delhaes, L
Abessolo, H
Biot, C
Berry, L
Delcourt, P
Maciejewski, L
Brocard, J
Camus, D
Dive, D
PARASITOLOGY RESEARCH, 2001, 87 (03) : 239 - 244
[25] PROVEBLUE (METHYLENE BLUE): A PROMISING ANTIMALARIAL DRUG
Pradines, Bruno
Dormoi, Jerome
Madamet, Marylin
Fall, Becaye
Amalvict, Remy
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2015, 93 (04): : 467 - 467
[26] Evidence basis for antimalarial policy change in Sierra Leone:: five in vivo efficacy studies of chloroquine, sulphadoxine-pyrimethamine and amodiaquine
Checchi, F
Roddy, P
Kamara, S
Williams, A
Morineau, G
Wurie, AR
Hora, B
de Lamotte, N
Baerwaldt, T
Heinzelmann, A
Danks, A
Pinoges, L
Oloo, A
Durand, M
Ranford-Cartwright, L
de Smet, M
TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2005, 10 (02) : 146 - 153
[27] ANTIMALARIAL ACTIVITY AND TOXICITY OF A METABOLIC DERIVATIVE OF QUININE
KELSEY, FE
OLDHAM, FK
CANTRELL, W
GEILING, EMK
NATURE, 1946, 157 (3988) : 440 - 440
[28] Synergistic in vitro antimalarial activity of omeprazole and quinine
Skinner-Adams, T
Davis, TME
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (05) : 1304 - 1306
[29] Evaluation of the genotoxic effects of pyrimethamine, an antimalarial drug, in the in vivo mouse
Vijayalaxmi, KK
Vishalakshi, M
TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS, 2000, 20 (02): : 65 - 71
[30] Plasmodium falciparum malaria:: Rosettes are disrupted by quinine, artemisinin, mefloquine primaquine, pyrimethamine, chloroquine and proguanil
Goldring, JPD
Padayachee, T
Ismail, I
MEMORIAS DO INSTITUTO OSWALDO CRUZ, 1999, 94 (05): : 667 - 673

← 1 2 3 4 5 →