The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

被引：12

作者：

Garavito, Giovanny ^{[1
]}

Bertani, Stephane ^{[2
,3
]}

Quiliano, Miguel ^{[4
]}

Valentin, Alexis ^{[2
]}

Aldana, Ignacio ^{[4
]}

Deharo, Eric ^{[2
,5
]}

机构：

[1] Univ Nacl Colombia, Dept Farm, Fac Ciencias, Bogota, Colombia

[2] Univ Toulouse 3, Univ Toulouse, Pharma Dev UMR 152, Fac Pharm, F-31062 Toulouse, France

[3] Inst Rech Dev, Pharma Dev UMR 152, Lima, Peru

[4] Univ Navarra, Neglected Dis Sect, Drug R&D Unit, Ctr Appl Pharmacobiol Res, E-31080 Pamplona, Spain

[5] Inst Rech Dev, Pharma Dev UMR 152, Fac Pharm, Toulouse, France

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2012年 / 107卷 / 06期

关键词：

antimalarials; methylene blue; drug combination; PLASMODIUM-FALCIPARUM; GLUTATHIONE-REDUCTASE; VITRO ASSESSMENT; COMBINATION; MALARIA; DRUG; ERYTHROCYTES; RESISTANCE; SAFETY;

D O I：

10.1590/S0074-02762012000600019

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

引用

页码：820 / 823

页数：4

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