Biologically Responsive Polymeric Nanoparticles for Drug Delivery

被引：180
|
作者：
Colson, Yolonda L. [1 ]
Grinstaff, Mark W. [2 ,3 ]
机构：
[1] Brigham & Womens Hosp, Dept Surg, Div Thorac Surg, Boston, MA 02215 USA
[2] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
[3] Boston Univ, Dept Chem, Boston, MA 02215 USA
来源：
ADVANCED MATERIALS | 2012年 / 24卷 / 28期
基金：
美国国家科学基金会;
关键词：
responsive system; triggered drug delivery; nanoparticles; pH; oxidation; POLY(BETA-AMINO ESTER) NANOPARTICLES; TUMOR-TARGETED DELIVERY; PH-SENSITIVE SYSTEM; LOADED EXPANSILE NANOPARTICLES; IN-VIVO; HYDROPHOBIC DRUGS; LYMPH-NODES; PACLITAXEL; PARTICLES; DEGRADATION;
D O I：
10.1002/adma.201200420
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Responsive nanoparticles that release their drug cargo in accordance with a change in pH or oxidative stress are of significant clinical interest as this approach offers the opportunity to link drug delivery to a specific location or disease state. This research news article reviews the current state of this field by examining a series of published articles that highlight the novelty and benefits of using responsive polymeric particles to achieve functionally-targeted drug delivery.
引用
收藏
页码：3878 / 3886
页数：9
相关论文
共 50 条
  • [31] Expansile Nanoparticles: Synthesis, Characterization, and in Vivo Efficacy of an Acid-Responsive Polymeric Drug Delivery System
    Griset, Aaron P.
    Walpole, Joseph
    Liu, Rong
    Gaffey, Ann
    Colson, Yolonda L.
    Grinstaff, Mark W.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (07) : 2469 - +
  • [32] Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery
    Cheng, Ru
    Meng, Fenghua
    Deng, Chao
    Klok, Harm-Anton
    Zhong, Zhiyuan
    BIOMATERIALS, 2013, 34 (14) : 3647 - 3657
  • [33] A monolithic polymeric microdevice for pH-responsive drug delivery
    Chen, Jian
    Chu, Michael
    Koulajian, Khajag
    Wu, Xiao Yu
    Giacca, Adria
    Sun, Yu
    BIOMEDICAL MICRODEVICES, 2009, 11 (06) : 1251 - 1257
  • [34] A monolithic polymeric microdevice for pH-responsive drug delivery
    Jian Chen
    Michael Chu
    Khajag Koulajian
    Xiao Yu Wu
    Adria Giacca
    Yu Sun
    Biomedical Microdevices, 2009, 11 : 1251 - 1257
  • [35] Stimuli-Responsive Polymeric Microneedles for Transdermal Drug Delivery
    Chen, Yonghang
    Li, Xinfang
    Yu, Weijiang
    Wang, Youxiang
    PROGRESS IN CHEMISTRY, 2021, 33 (07) : 1138 - 1160
  • [36] pH-Responsive polymeric carriers for siRNA drug delivery
    Stayton, Patrick
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [37] pH-responsive polymeric vesicles as drug delivery systems
    Dubos, Ashley
    Fish, Daryle
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
  • [38] Capsules with responsive polymeric shells for applications beyond drug delivery
    Wang, Yifei
    Starvaggi, Nicholas
    Pentzer, Emily
    POLYMER CHEMISTRY, 2023, 14 (35) : 4033 - 4047
  • [39] Stimuli-Responsive Polymeric Nanosystems for Controlled Drug Delivery
    Xiang, Zhichu
    Liu, Mouquan
    Song, Jun
    APPLIED SCIENCES-BASEL, 2021, 11 (20):
  • [40] Reduction-responsive polymeric micelles for anticancer drug delivery
    Jiang, Xulin
    Li, Lihua
    Liu, Jia
    Zhuo, Renxi
    JOURNAL OF CONTROLLED RELEASE, 2011, 152 : E36 - E37
12345