Biologically Responsive Polymeric Nanoparticles for Drug Delivery

被引：180
|
作者：
Colson, Yolonda L. [1 ]
Grinstaff, Mark W. [2 ,3 ]
机构：
[1] Brigham & Womens Hosp, Dept Surg, Div Thorac Surg, Boston, MA 02215 USA
[2] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
[3] Boston Univ, Dept Chem, Boston, MA 02215 USA
来源：
ADVANCED MATERIALS | 2012年 / 24卷 / 28期
基金：
美国国家科学基金会;
关键词：
responsive system; triggered drug delivery; nanoparticles; pH; oxidation; POLY(BETA-AMINO ESTER) NANOPARTICLES; TUMOR-TARGETED DELIVERY; PH-SENSITIVE SYSTEM; LOADED EXPANSILE NANOPARTICLES; IN-VIVO; HYDROPHOBIC DRUGS; LYMPH-NODES; PACLITAXEL; PARTICLES; DEGRADATION;
D O I：
10.1002/adma.201200420
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Responsive nanoparticles that release their drug cargo in accordance with a change in pH or oxidative stress are of significant clinical interest as this approach offers the opportunity to link drug delivery to a specific location or disease state. This research news article reviews the current state of this field by examining a series of published articles that highlight the novelty and benefits of using responsive polymeric particles to achieve functionally-targeted drug delivery.
引用
收藏
页码：3878 / 3886
页数：9
相关论文
共 50 条
  • [21] Polymeric nanoparticles for sensor and drug delivery applications
    Schubert, Stephanie
    Vollrath, Antje
    Perevyazko, Igor
    Fischer, Dagmar
    Schubert, Ulrich S.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [22] siRNA drug delivery by biodegradable polymeric nanoparticles
    Yuan, Xudong
    Li, Ling
    Rathinavelu, Appu
    Hao, Jinsong
    Narasimhan, Madhusudhanan
    He, Matthew
    Heitlage, Viviene
    Tam, Linda
    Viqar, Sana
    Salehi, Mojgan
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2006, 6 (9-10) : 2821 - 2828
  • [23] Biodegradable polymeric nanoparticles as drug delivery devices
    Soppimath, KS
    Aminabhavi, TM
    Kulkarni, AR
    Rudzinski, WE
    JOURNAL OF CONTROLLED RELEASE, 2001, 70 (1-2) : 1 - 20
  • [24] Applications of polymeric nanoparticles in drug delivery for glioblastoma
    Liu, Shuhan
    Tan, Bin
    Wang, Feng
    Yu, Ying
    FRONTIERS IN PHARMACOLOGY, 2025, 15
  • [25] Polymeric Nanoparticles for Brain Drug Delivery - A Review
    Raman, Subashini
    Mahmood, Syed
    Hilles, Ayah R.
    Javed, Md Noushad
    Azmana, Motia
    Al-Japairai, Khater Ahmed Saeed
    CURRENT DRUG METABOLISM, 2020, 21 (09) : 649 - 660
  • [26] Biodegradable Polymeric Nanoparticles as the Delivery Carrier for Drug
    Zhao, Kai
    Li, Dan
    Shi, Ci
    Ma, Xueling
    Rong, Guangu
    Kang, Hong
    Wang, Xiaohua
    Sun, Bin
    CURRENT DRUG DELIVERY, 2016, 13 (04) : 494 - 499
  • [27] pH-Responsive Nanoparticles for Drug Delivery
    Gao, Weiwei
    Chan, Juliana M.
    Farokhzad, Omid C.
    MOLECULAR PHARMACEUTICS, 2010, 7 (06) : 1913 - 1920
  • [28] Light-responsive polymeric nanoparticles for retinal drug delivery: design cues, challenges and future perspectives
    Guidi, Lorenzo
    Cascone, Maria Grazia
    Rosellini, Elisabetta
    HELIYON, 2024, 10 (05)
  • [29] Phenylboronic acid-based glucose-responsive polymeric nanoparticles: synthesis and applications in drug delivery
    Ma, Rujiang
    Shi, Linqi
    POLYMER CHEMISTRY, 2014, 5 (05) : 1503 - 1518
  • [30] Expansile nanoparticles: Synthesis, characterization, and in vivo efficacy of an acid-responsive polymeric drug delivery system
    Griset, Aaron P.
    Walpole, Joseph
    Liu, Rong
    Gaffey, Ann
    Colson, Yolonda L.
    Grinstaff, Mark W.
    Journal of the American Chemical Society, 2009, 131 (07): : 2469 - 2471
12345