Relief with Rapamycin: mTOR Inhibition Protects against Radiation-Induced Mucositis

被引：7
|
作者：
Finkel, Toren [1 ]
机构：
[1] NHLBI, Ctr Mol Med, NIH, Bethesda, MD 20892 USA
来源：
CELL STEM CELL | 2012年 / 11卷 / 03期
关键词：
HEMATOPOIETIC STEM-CELLS;
D O I：
10.1016/j.stem.2012.08.003
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
In this issue of Cell Stem Cell, Iglesias-Bartolome et al. (2012) show that mTOR inhibition with rapamycin protects against mucositis in mice, suggesting potential treatment strategies against this harmful side effect of anticancer therapies. In normal tissues, rapamycin prevents epithelial stem cell senescence by reducing oxidative stress through increased MnSOD.
引用
收藏
页码：287 / 288
页数：2
相关论文
共 50 条
  • [31] Disulfiram Protects Against Radiation-Induced Intestinal Injury in Mice
    Yuan, Qingwen
    Peng, Renjun
    Yu, Huijie
    Wang, Sinian
    Chen, Zhongmin
    Dong, Suhe
    Li, Wei
    Cheng, Bo
    Jiang, Qisheng
    Cong, Yuwen
    Li, Fengsheng
    Li, Changzheng
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [32] Faecal microbiota transplantation protects against radiation-induced toxicity
    Cui, Ming
    Xiao, Huiwen
    Li, Yuan
    Zhou, Lixin
    Zhao, Shuyi
    Luo, Dan
    Zheng, Qisheng
    Dong, Jiali
    Zhao, Yu
    Zhang, Xin
    Zhang, Junling
    Lu, Lu
    Wang, Haichao
    Fan, Saijun
    EMBO MOLECULAR MEDICINE, 2017, 9 (04) : 448 - 461
  • [33] The circadian clock protects against ionizing radiation-induced cardiotoxicity
    Dakup, Panshak P.
    Porter, Kenneth I.
    Gajula, Rajendra P.
    Goel, Peeyush N.
    Cheng, Zhaokang
    Gaddameedhi, Shobhan
    FASEB JOURNAL, 2020, 34 (02): : 3347 - 3358
  • [34] Inhibition of Caspases Protects Mice from Radiation-induced Oral Mucositis and Abolishes the Cleavage of RNA-binding Protein HuR
    Talwar, Sudha
    House, Reniqua
    Sundaramurthy, Santhanalakshmi
    Balasubramanian, Sundaravadivel
    Yu, Hong
    Palanisamy, Viswanathan
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (06) : 3487 - 3500
  • [35] Cytoprotective effects of amifostine and melatonin against radiation-induced oral mucositis in rats
    Park, D.
    Kim, D. H.
    Kim, W. T.
    Nam, J. H.
    Kim, D. C.
    Lee, K. H.
    Ki, Y. K.
    Joo, J. H.
    Jeon, H. S.
    INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 2023, 21 (02): : 261 - 265
  • [36] Effect of Epicatechin against Radiation-Induced Oral Mucositis: In Vitro and In Vivo Study
    Shin, Yoo Seob
    Shin, Hyang Ae
    Kang, Sung Un
    Kim, Jang Hee
    Oh, Young-Taek
    Park, Keun Hyung
    Kim, Chul-Ho
    PLOS ONE, 2013, 8 (07):
  • [37] Glucosamine protects against radiation-induced lung injury via inhibition of epithelial-mesenchymal transition
    Lei, Xiao
    Ma, Na
    Liang, Yanjie
    Liu, Junyan
    Zhang, Pei
    Han, Yanan
    Chen, Wei
    Du, Lehui
    Qu, Baolin
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (18) : 11018 - 11023
  • [38] Tetrahydrobiopterin Protects against Radiation-induced Growth Inhibition in H9c2 Cardiomyocytes
    Zhang, Zheng-Yi
    Li, Yi
    Li, Rui
    Zhang, An-An
    Shang, Bo
    Yu, Jing
    Xie, Xiao-Dong
    CHINESE MEDICAL JOURNAL, 2016, 129 (22) : 2733 - 2740
  • [39] Tetrahydrobiopterin Protects against Radiation-induced Growth Inhibition in H9c2 Cardiomyocytes
    Zheng-Yi Zhang
    Yi Li
    Rui Li
    An-An Zhang
    Bo Shang
    Jing Yu
    Xiao-Dong Xie
    中华医学杂志(英文版), 2016, 129 (22) : 2733 - 2740
  • [40] PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2
    Taniguchi, Cullen M.
    Miao, Yu Rebecca
    Diep, Anh N.
    Wu, Colleen
    Rankin, Erinn B.
    Atwood, Todd F.
    Xing, Lei
    Giaccia, Amato J.
    SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (236)
12345