Relief with Rapamycin: mTOR Inhibition Protects against Radiation-Induced Mucositis

被引：7
|
作者：
Finkel, Toren [1 ]
机构：
[1] NHLBI, Ctr Mol Med, NIH, Bethesda, MD 20892 USA
来源：
CELL STEM CELL | 2012年 / 11卷 / 03期
关键词：
HEMATOPOIETIC STEM-CELLS;
D O I：
10.1016/j.stem.2012.08.003
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
In this issue of Cell Stem Cell, Iglesias-Bartolome et al. (2012) show that mTOR inhibition with rapamycin protects against mucositis in mice, suggesting potential treatment strategies against this harmful side effect of anticancer therapies. In normal tissues, rapamycin prevents epithelial stem cell senescence by reducing oxidative stress through increased MnSOD.
引用
收藏
页码：287 / 288
页数：2
相关论文
共 50 条
  • [21] The Effects of Royal Jelly Against Radiation-Induced Acute Oral Mucositis
    Cihan, Yasemin B.
    Deniz, Kemal
    UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, 2014, 24 (01): : 36 - 44
  • [22] A rat model against chemotherapy plus radiation-induced oral mucositis
    Patel, Alkesh
    Rajesh, S.
    Chandrashekhar, V. M.
    Rathnam, Shivprakash
    Shah, Karishma
    Rao, C. Mallikarjuna
    Nandakumar, K.
    SAUDI PHARMACEUTICAL JOURNAL, 2013, 21 (04) : 399 - 403
  • [23] Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development
    Liu, Yueyong
    Huang, Yurong
    Wang, Zeran
    Huang, Yong
    Li, Xiaohua
    Louie, Alexander
    Wei, Guangwei
    Mao, Jian-Hua
    AGING-US, 2013, 5 (02): : 111 - 119
  • [24] Inhibition of PCSK9 protects against radiation-induced damage of prostate cancer cells
    Gan, Si-Shun
    Ye, Jian-Qing
    Wang, Lei
    Qu, Fa-Jun
    Chu, Chuan-Min
    Tian, Yi-Jun
    Yang, Wei
    Cui, Xin-Gang
    ONCOTARGETS AND THERAPY, 2017, 10 : 2139 - 2146
  • [25] Lycopene protects against ionizing radiation-induced testicular damage by inhibition of apoptosis and mitochondrial dysfunction
    Qu, Mingyue
    He, Qican
    Guo, Baoshi
    FOOD SCIENCE & NUTRITION, 2024, 12 (01): : 534 - 546
  • [26] Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice
    Wei, Liang
    Leibowitz, Brian J.
    Wang, Xinwei
    Epperly, Michael
    Greenberger, Joel
    Zhang, Lin
    Yu, Jian
    JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (11): : 4076 - 4087
  • [27] Prevention of radiation-induced mucositis.
    Johnson J.T.
    Current Oncology Reports, 2001, 3 (1) : 56 - 58
  • [28] Mammalian Target of Rapamycin Inhibition With Rapamycin Mitigates Radiation-Induced Pulmonary Fibrosis in a Murine Model
    Chung, Eun Joo
    Sowers, Anastasia
    Thetford, Angela
    McKay-Corkum, Grace
    Chung, Su I.
    Mitchell, James B.
    Citrin, Deborah E.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2016, 96 (04): : 857 - 866
  • [29] Modulation of radiation-induced oral mucositis (mouse) by selective inhibition of β1 integrin
    Albert, Maria
    Schmidt, Margret
    Cordes, Nils
    Doerr, Wolfgang
    RADIOTHERAPY AND ONCOLOGY, 2012, 104 (02) : 230 - 234
  • [30] The circadian clock protects against acute radiation-induced dermatitis
    Dakup, Panshak P.
    Porter, Kenneth, I
    Gaddameedhi, Shobhan
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 399
12345