Relief with Rapamycin: mTOR Inhibition Protects against Radiation-Induced Mucositis

被引：7
|
作者：
Finkel, Toren [1 ]
机构：
[1] NHLBI, Ctr Mol Med, NIH, Bethesda, MD 20892 USA
来源：
CELL STEM CELL | 2012年 / 11卷 / 03期
关键词：
HEMATOPOIETIC STEM-CELLS;
D O I：
10.1016/j.stem.2012.08.003
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
In this issue of Cell Stem Cell, Iglesias-Bartolome et al. (2012) show that mTOR inhibition with rapamycin protects against mucositis in mice, suggesting potential treatment strategies against this harmful side effect of anticancer therapies. In normal tissues, rapamycin prevents epithelial stem cell senescence by reducing oxidative stress through increased MnSOD.
引用
收藏
页码：287 / 288
页数：2
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