Austdiol, fulvic acid and citromycetin derivatives from an endolichenic fungus, Myxotrichum sp.

被引：26
|
作者：
Yuan, Chao [1 ,2 ]
Wang, Hai-Ying [4 ]
Wu, Chang-Sheng [3 ]
Jiao, Yang [3 ]
Li, Ming [4 ]
Wang, Yan-Yan [3 ]
Wang, Shu-Qi [3 ]
Zhao, Zun-Tian [4 ]
Lou, Hong-Xiang [3 ]
机构：
[1] Chinese Acad Med Sci, Inst Med Plant Dev Yunnan Branch, Jinghong 666100, Peoples R China
[2] Peking Union Med Coll, Jinghong 666100, Peoples R China
[3] Shandong Univ, Dept Nat Prod Chem, Key Lab Chem Biol, Minist Educ,Sch Pharmaceut Sci, Jinan 250012, Peoples R China
[4] Shandong Normal Univ, Coll Life Sci, Jinan 250014, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2013年 / 6卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Endolichenic fungus; Metabolites; Antigungal activity; Cytotoxicity; DIKETOPIPERAZINES; HEPTAKETIDES; METABOLITES;
D O I：
10.1016/j.phytol.2013.08.011
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new austdiol analog myxodiol A (1), three novel fulvic acid derivatives myxotrichin A-C (2-4), and a new citromycetin analog myxotrichin D (5), were isolated from an endolichenic fungus Myxotrichum sp. inhabiting the lichen Cetraria islandica (L.) Ach. The structures of these compounds were elucidated unequivocally on the basis of comprehensive analysis of MS and NMR data. Compounds 2 and 5 displayed very weak cytotoxicity against human leukemia cell line K562, and compounds 1 showed very weak antifungal activity against Candida albicans (sc5314). (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：662 / 666
页数：5
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