Regiospecific hydration of γ-hydroxy-α,β-acetylenic esters:: A novel asymmetric synthesis of tetronic acids

被引：65
|
作者：
Rajaram, AR [1 ]
Pu, L [1 ]
机构：
[1] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA
来源：
ORGANIC LETTERS | 2006年 / 8卷 / 10期
关键词：
D O I：
10.1021/ol060377v
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The optically active gamma-hydroxy-alpha,beta-acetylenic esters are obtained from the enantioselective reaction of methyl propiolate with both aliphatic and aromatic aldehydes. These compounds can undergo regiospecific hydration in the presence of Zeise's dimer, [PtCl2(C2H4)](2), to generate the optically active tetronic acids.
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页码：2019 / 2021
页数：3
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