Regiospecific hydration of γ-hydroxy-α,β-acetylenic esters:: A novel asymmetric synthesis of tetronic acids

被引：65

作者：

Rajaram, AR ^{[1
]}

Pu, L ^{[1
]}

机构：

[1] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 10期

关键词：

D O I：

10.1021/ol060377v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The optically active gamma-hydroxy-alpha,beta-acetylenic esters are obtained from the enantioselective reaction of methyl propiolate with both aliphatic and aromatic aldehydes. These compounds can undergo regiospecific hydration in the presence of Zeise's dimer, [PtCl2(C2H4)](2), to generate the optically active tetronic acids.

引用

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页码：2019 / 2021

页数：3

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