γ-Hydroxy-α,β-acetylenic esters:asymmetric syntheses and applications

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GAO Ge PU Lin Department of ChemistrySichuan UniversityChengdu ChinaDepartment of ChemistryUniversity of VirginiaCharlottesvilleVirginia USA [1 ,2 ,1 ,610064 ,2 ,22904 ,4319 ]
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Science China(Chemistry) | 2010年 / 53卷 / 01期
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摘要：
γ-Hydroxy-α,β-acetylenic esters are versatile synthetic precursors to many organic compounds.This paper reviews the synthesis of chiral γ-hydroxy-α,β-acetylenic esters by asymmetric reduction of γ-oxo-α,β-acetylenic esters,enantioselective addition to aldehydes in the presence of chiral catalysts,and diastereoselective addition to chiral aldehydes.The preparation of racemic γ-hydroxy-α,β-acetylenic esters is also included.Examples are provided for the application of γ-hydroxy-α,β-acetylenic esters in organic synthesis.
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页码：21 / 35
页数：15
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