Generation of an induced pluripotent stem cell line (GIBHi004-A) from a Parkinson's disease patient with mutant DJ-1/PARK7 (p.L10P)

被引：2

作者：

Li, Yunpan ^{[1
,2
,3
]}

Ibanez, David P. ^{[1
,2
,3
,4
]}

Fan, Wenxia ^{[5
]}

Zhao, Ping ^{[6
]}

Chen, Shuhan ^{[1
,2
,3
,4
]}

Abdul, Mazid Md ^{[1
,2
,3
]}

Jiang, Yu ^{[1
,2
,3
]}

Fu, Lixin ^{[1
,2
,3
,4
]}

Luo, Zhiwei ^{[5
]}

Liu, Zhenhua ^{[7
,8
]}

Yang, Yueli ^{[9
]}

Guo, Jifeng ^{[7
,8
]}

Volpe, Giacomo ^{[1
,2
,3
]}

Kanwal, Shahzina ^{[1
,2
,3
]}

Wang, Dongye ^{[1
,2
,3
]}

Tang, Beisha ^{[7
,8
]}

Li, Wenjuan ^{[1
,2
,3
,5
]}

机构：

[1] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Integrat Biol, Guangzhou 510530, Peoples R China

[2] Key Lab Regenerat Biol, Guangzhou 510530, Peoples R China

[3] Guangdong Prov Key Lab Stem Cells & Regenerat Med, Guangzhou 510530, Peoples R China

[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[5] Guangzhou Med Univ, Guangzhou 511436, Peoples R China

[6] Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou 510005, Peoples R China

[7] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Peoples R China

[8] Cent South Univ, Natl Clin Res Ctr Geriatr Dis, Changsha 410008, Peoples R China

[9] Jilin Univ, Coll Vet Med, Changchun 130062, Peoples R China

来源：

STEM CELL RESEARCH | 2020年 / 46卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

DJ-1;

D O I：

10.1016/j.scr.2020.101845

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mutations occurring in the gene body of PARK7 (encoding DJ-1/PARK7) cause autosomal recessive early-onset parkinsonism (AREP). These mutations produce a loss of function and have been reported to lead to dopaminergic neuron degeneration in the substantia nigra. However, the underlying mechanisms are largely unknown. Here, we report the generation of a patient-derived induced pluripotent stem cell (iPSC) line carrying mutant DJ-1 (p.L10P). This cell line is a valuable tool for in vitro Parkinson's disease (PD) modeling and mechanistic studies.

引用

页数：5

共 50 条

[31] Reprogramming of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient with a R1628P variant in the LRRK2 gene
Ma, Dongrui
Zhou, Wei
Ng, Ebonne Yulin
Zeng, Li
Zhao, Yi
Tan, Eng King
STEM CELL RESEARCH, 2017, 18 : 45 - 47
[32] Generation of an induced pluripotent stem cell (iPSC) line from a Parkinson 's disease patient with a pathogenic LRP10/c.688C > T(p. Arg230Trp) mutation
Wang, Yan
Wei, Chuanfei
Liu, Yanming
Lu, Xianjie
Wang, Wei
Song, Na
Zhang, Wei
Xu, Jun
Zhang, Wei
Han, Fabin
STEM CELL RESEARCH, 2024, 77
[33] Generation of an induced pluripotent stem cell line (TRNDi004-I) from a Niemann-Pick disease type B patient carrying a heterozygous mutation of p.L43_A44delLA in the SMPD1 gene
Baskfield, Amanda
Li, Rong
Beers, Jeanette
Zou, Jizhong
Liu, Chengyu
Zheng, Wei
STEM CELL RESEARCH, 2019, 37
[34] Generation of an induced pluripotent stem cell line (EURACi005-A) from a Parkinson's disease patient carrying a homozygous exon 3 deletion in the PRKNgene
Zanon, Alessandra
Riekschnitz, Diana
von Troyer, Michael
Volpato, Claudia
Picard, Anne
Cantaloni, Chiara
Di Segni, Marina
Silipigni, Rosamaria
Pramstaller, Peter P.
Hicks, Andrew A.
Pichler, Irene
STEM CELL RESEARCH, 2019, 41
[35] Generation of an induced pluripotent stem cell line (KNIHi001-A) by reprogramming peripheral blood mononuclear cells isolated from a patient with Parkinson's disease
Baek, Daye
Lee, Kun-Gu
Sohn, Hee-Young
Park, Jung Hyun
Lee, Hye-Kyung
Bayarsaikhan, Govigerel
Yoo, Sang-Won
Lee, Bonghee
Kim, Joong-Seok
Koh, Young Ho
Kwon, Munjin
STEM CELL RESEARCH, 2024, 76
[36] Generation of an induced pluripotent stem cell line from patient with atrial fibrillation with KCNQ1 p.Ser209Pro mutation
Cen, Yunguang
Zhou, Tiancheng
Chen, Songsheng
Deng, Zhanyu
Wang, Jianshuo
Ma, Ning
Zhang, Shaoheng
STEM CELL RESEARCH, 2024, 76
[37] Generation of an induced pluripotent stem cell line from a Huntington?s disease patient with a long HTT-PolyQ sequence
Miller, Duncan C.
Lisowski, Pawel
Genehr, Carolin
Wanker, Erich E.
Priller, Josef
Prigione, Alessandro
Diecke, Sebastian
STEM CELL RESEARCH, 2023, 68
[38] Familial Parkinson's Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2
Fu, Kai
Wang, Yanfei
Guo, Dongkai
Wang, Guanghui
Ren, Haigang
NEUROSCIENCE BULLETIN, 2017, 33 (06) : 685 - 694
[39] Familial Parkinson’s Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2
Kai Fu
Yanfei Wang
Dongkai Guo
Guanghui Wang
Haigang Ren
Neuroscience Bulletin, 2017, 33 : 685 - 694
[40] Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion
Madencioglu, Deniz A.
Kruth, Karina
Shin, Mallory
Andreasen, Nancy
Wassink, Thomas
Williams, Aislinn
STEM CELL RESEARCH, 2022, 59

← 1 2 3 4 5 →