Catalytic asymmetric conjugate addition of Grignard reagents to chromones

被引：49

作者：

Vila, Carlos ^{[1
]}

Hornillos, Valentin ^{[1
]}

Fananas-Mastral, Martin ^{[1
]}

Feringa, Ben L. ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 53期

关键词：

PHOSPHINE-PHOSPHITE LIGANDS; 2-SUBSTITUTED CHROMAN-4-ONES; ENANTIOSELECTIVE SYNTHESIS; MICHAEL ADDITION; CHROMANONES; COMPLEXES; ENONES; 1,4-ADDITION; CONSTRUCTION; FLAVANONES;

D O I：

10.1039/c3cc43105c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly regio- and enantioselective copper catalysed direct conjugate addition of Grignard reagents to chromones has been developed taking advantage of the reduced reactivity of the resulting magnesium enolates. This methodology tolerates a broad scope of alkyl Grignards including secondary alkyl magnesium reagents as well as functionalised chromones.

引用

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页码：5933 / 5935

页数：3

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