Catalytic asymmetric conjugate addition of Grignard reagents to chromones

被引：49
|
作者：
Vila, Carlos [1 ]
Hornillos, Valentin [1 ]
Fananas-Mastral, Martin [1 ]
Feringa, Ben L. [1 ]
机构：
[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 53期
关键词：
PHOSPHINE-PHOSPHITE LIGANDS; 2-SUBSTITUTED CHROMAN-4-ONES; ENANTIOSELECTIVE SYNTHESIS; MICHAEL ADDITION; CHROMANONES; COMPLEXES; ENONES; 1,4-ADDITION; CONSTRUCTION; FLAVANONES;
D O I：
10.1039/c3cc43105c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly regio- and enantioselective copper catalysed direct conjugate addition of Grignard reagents to chromones has been developed taking advantage of the reduced reactivity of the resulting magnesium enolates. This methodology tolerates a broad scope of alkyl Grignards including secondary alkyl magnesium reagents as well as functionalised chromones.
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页码：5933 / 5935
页数：3
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