Relationship between Metabolic Syndrome and its Components with Coronary Heart Disease in Iranian Men and Women

Introduction: Although metabolic syndrome (MetS) is receiving increased attention from physicians, data on the syndrome's association with coronary heart disease (CHD) in Iranian populations are limited. Materials and Methods: To estimate the odds ratio (OR) of MetS defined by each of the International Diabetes Federation (IDF), the Adult Treatment Panel (ATPIII) and the WHO definitions for CHD, logistic regression analysis was used on 5981 subjects aged >= 30 years, in both sexes in 3 models; model 1 an age adjusted model, model 2 adjusted for age, smoking status, premature history of CHD and LDL cholesterol and model 3 adjusted for mentioned variables plus the MetS components. Results: The MetS defined by all the three definitions was associated with CHD in models 1 and 2. The relatively highest odds ratio (95% CI) of MetS for CHD was defined in model 2 by definition in men (2.3 (1.8-3)) and the ATPIII in women (1.6 (1.3-2)). In model 3, lost its association with CHD; in men high fasting plasma glucose and high blood (plus obesity by the WHO definition) in women, high blood pressure (plus high circumference by the ATPIII, obesity and domain by the WHO definition) remained with CHD. Conclusions: In Iranian men and women, three definitions of MetS were associated CHD when considering the conventional risk After further adjusting MetS none of these definitions showed with CHD and only high blood pressure related to CHD in both sexes in all definitions.