ent-Strobane and ent-Pimarane Diterpenoids from Siegesbeckia pubescens

被引：42

作者：

Wang, Jianbin ^{[1
]}

Duan, Hongquan ^{[2
]}

Wang, Yi ^{[1
]}

Pan, Bowen ^{[1
]}

Gao, Chun ^{[1
]}

Gai, Chunyan ^{[1
]}

Wu, Qiong ^{[1
]}

Fu, Hongzheng ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[2] Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 01期

基金：

中国国家自然科学基金;

关键词：

STEM BARK; KIRENOL; CELLS; ORIENTALIS;

D O I：

10.1021/acs.jnatprod.6b00150

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two strobane diterpenoids, strobols A (1) and B (2), 15 new pimarane diterpenoids (3-6 and 8-18), and the known compounds kirenol (19), darutigenol (20), and ent-2 beta,15,16,19-tetrahydroxypimar-8(14)-ene (7) were isolated from the aerial parts of Siegesbeckia pubescens Makino. The structures of the new compounds were established based on the interpretation of HRESIMS and NMR analysis. The configurations of 1, 6, and 17 were confirmed by X-ray-crystallographic data. Compounds 3, 5, and 11 inhibited the migration of MB-MDA-231 breast cancer cells induced by the chemokine epithelial growth factor, with IC50 values of 4.26, 3.45, and 9.70 mu M, respectively.

引用

页码：19 / 29

页数：11

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