ent-Strobane and ent-Pimarane Diterpenoids from Siegesbeckia pubescens

被引：42

作者：

Wang, Jianbin ^{[1
]}

Duan, Hongquan ^{[2
]}

Wang, Yi ^{[1
]}

Pan, Bowen ^{[1
]}

Gao, Chun ^{[1
]}

Gai, Chunyan ^{[1
]}

Wu, Qiong ^{[1
]}

Fu, Hongzheng ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[2] Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 01期

基金：

中国国家自然科学基金;

关键词：

STEM BARK; KIRENOL; CELLS; ORIENTALIS;

D O I：

10.1021/acs.jnatprod.6b00150

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two strobane diterpenoids, strobols A (1) and B (2), 15 new pimarane diterpenoids (3-6 and 8-18), and the known compounds kirenol (19), darutigenol (20), and ent-2 beta,15,16,19-tetrahydroxypimar-8(14)-ene (7) were isolated from the aerial parts of Siegesbeckia pubescens Makino. The structures of the new compounds were established based on the interpretation of HRESIMS and NMR analysis. The configurations of 1, 6, and 17 were confirmed by X-ray-crystallographic data. Compounds 3, 5, and 11 inhibited the migration of MB-MDA-231 breast cancer cells induced by the chemokine epithelial growth factor, with IC50 values of 4.26, 3.45, and 9.70 mu M, respectively.

引用

页码：19 / 29

页数：11

共 50 条

[31] Tedanol: A potent anti-inflammatory ent-pimarane diterpene from the Caribbean Sponge Tedania ignis
Costantino, Valeria
Fattorusso, Ernesto
Mangoni, Alfonso
Perinu, Cristina
Cirino, Giuseppe
De Gruttola, Luana
Roviezzo, Fiorentina
BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (21) : 7542 - 7547
[32] Ent-kaurane and ent-abietane diterpenoids from Isodon phyllostachys
Jin Yang
Yaqi An
Haiyan Wu
Miao Liu
Weiguang Wang
Xue Du
Yan Li
Jianxin Pu
Handong Sun
Science China(Chemistry), 2016, (09) : 1211 - 1215
[33] Ent-clerodane and ent-trachylobane diterpenoids from Croton dictyophlebodes
Munissi, Joan J. E.
Isyaka, Sani M.
Mas-Claret, Eduard
Brabner, Molly
Langat, Moses K.
Nyandoro, Stephen S.
Mulholland, Dulcie A.
PHYTOCHEMISTRY, 2020, 179
[34] Ent-kaurane and ent-abietane diterpenoids from Isodon phyllostachys
Jin Yang
Yaqi An
Haiyan Wu
Miao Liu
Weiguang Wang
Xue Du
Yan Li
Jianxin Pu
Handong Sun
Science China Chemistry, 2016, 59 : 1211 - 1215
[35] Ent-abietane and ent-labdane diterpenoids from Isodon parvifolius
Li, -Mei Li
Huang, Sheng-Xiong
Peng, Li-Yan
Li, Guo-You
Xiao, Wei-Lie
Zhou, Yan
Han, Quan-Bin
Ding, Li-Sheng
Sun, Han-Dong
CHEMICAL & PHARMACEUTICAL BULLETIN, 2006, 54 (07) : 1050 - 1052
[36] Highly Oxygenated ent-Pimarane-Type Diterpenoids from the Chinese Liverwort Pedinophyllum interruptum and Their Allelopathic Activities
Liu, Na
Li, Rui-Juan
Wang, Xiao-Ning
Zhu, Rong-Xiu
Wang, Lei
Lin, Zhao-Min
Zhao, Yu
Lou, Hong-Xiang
JOURNAL OF NATURAL PRODUCTS, 2013, 76 (09): : 1647 - 1653
[37] Ent-kaurane and ent-abietane diterpenoids from Isodon phyllostachys
Jin Yang
Yaqi An
Haiyan Wu
Miao Liu
Weiguang Wang
Xue Du
Yan Li
Jianxin Pu
Handong Sun
Science China(Chemistry), 2016, 59 (09) : 1211 - 1215
[38] Ent-kaurane and ent-abietane diterpenoids from Isodon phyllostachys
Yang, Jin
An, Yaqi
Wu, Haiyan
Liu, Miao
Wang, Weiguang
Du, Xue
Li, Yan
Pu, Jianxin
Sun, Handong
SCIENCE CHINA-CHEMISTRY, 2016, 59 (09) : 1211 - 1215
[39] ent-Atisane and ent-kaurane diterpenoids from Isodon rosthornii
Zhan, Rui
Li, Xiao-Nian
Du, Xue
Wang, Wei-Guang
Dong, Ke
Su, Jia
Li, Yan
Pu, Jian-Xin
Sun, Han-Dong
FITOTERAPIA, 2013, 88 : 76 - 81
[40] Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens
Valente, C
Pedro, M
Duarte, A
Nascimento, MSJ
Abreu, PM
Ferreira, MJU
JOURNAL OF NATURAL PRODUCTS, 2004, 67 (05): : 902 - 904

← 1 2 3 4 5 →