Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer

被引：71

作者：

Moreira, Leticia ^{[1
,2
,3
]}

Bakir, Basil ^{[1
,2
]}

Chatterji, Priya ^{[1
,2
]}

Dantes, Zahra ^{[4
]}

Reichert, Maximilian ^{[4
]}

Rustgi, Anil K. ^{[1
,2
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Med, Div Gastroenterol, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Dept Genet, Div Gastroenterol, Philadelphia, PA 19104 USA

[3] Univ Barcelona, IDIBAPS, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Hosp Clin,Dept Gastroenterol, Catalonia, Spain

[4] Tech Univ Munich, Klinikum Rechts Isar, Med Klin & Poliklin 2, Munich, Germany

来源：

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY | 2018年 / 5卷 / 03期

关键词：

3D Organoids; Pancreas; Adenocarcinoma; Personalized Medicine; ESOPHAGEAL EPITHELIAL-CELLS; STEM-CELLS; DUCTAL ADENOCARCINOMA; IN-VITRO; ONCOGENIC KRAS; DRUG RESPONSE; ADULT LIVER; MOUSE; CULTURE; SPHEROIDS;

D O I：

10.1016/j.jcmgh.2017.12.004

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the third leading cause of cancer-related mortality in the United States. Although important advances have been made in the last decade, the mortality rate of pancreatic ductal adenocarcinoma has not changed appreciably. This review summarizes a rapidly emerging model of pancreatic cancer research, focusing on 3-dimensional organoids as a powerful tool for several applications, but above all, representing a step toward personalized medicine.

引用

页码：289 / 298

页数：10

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