Epiregulin and Amphiregulin expression defines a subset of colorectal tumors sensitive to EGFR inhibition

被引:0
|
作者
Jacobs, Bart
Biesmans, Bart
De Roock, Wendy
De Schutter, Jef
Van Cutsem, Eric
Tejpar, Sabine
机构
[1] Katholieke Univ Leuven, Ctr Human Genet, Leuven, Belgium
[2] Univ Hosp Gasthuisberg, Digest Oncol Unit, Leuven, Belgium
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1346
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Use of epiregulin (EREG) and amphiregulin (AREG) gene expression to predict response to cetuximab (cet) in combination with oxaliplatin (Ox) and 5FU in the first-line treatment of advanced colorectal cancer (aCRC)
    Adams, Richard A.
    Fisher, David
    Farragher, Susan
    Jasani, Bharat
    Smith, Christopher G.
    James, Michelle D.
    Cheadle, Jeremy
    Nichols, Laura L.
    Meade, Angela M.
    Kaplan, Richard S.
    Wilson, Richard H.
    Wasan, Harpreet
    Maughan, Tim
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (30)
  • [42] AMPHIREGULIN AND EPIREGULIN EXPRESSION PREDICTS FOR TREATMENT EFFICACY IN METASTATIC COLORECTAL CANCER (MCRC) PATIENTS TREATED WITH CETUXIMAB PLUS CAPIRI OR CAPOX. ANALYSIS OF THE GERMAN AIO CRC GROUP TRIAL: KRK-0204
    Stintzing, Sebastian
    Jung, Andreas
    Kapaun, Christine
    Reiche, Jana
    Modest, Dominik
    Giessen, Clemens
    Vehling-Kaiser, Ursula
    Stauch, Martina
    Hass, Holger
    von Weikersthal, Ludwig Fischer
    Kirchner, Thomas
    Heinemann, Volker
    ANNALS OF ONCOLOGY, 2011, 22 : v16 - v16
  • [43] Impact of the 3D Microenvironment on Phenotype, Gene Expression, and EGFR Inhibition of Colorectal Cancer Cell Lines
    Luca, Anna C.
    Mersch, Sabrina
    Deenen, Rene
    Schmidt, Stephan
    Messner, Isabelle
    Schaefer, Karl-Ludwig
    Baldus, Stephan E.
    Huckenbeck, Wolfgang
    Piekorz, Roland P.
    Knoefel, Wolfram T.
    Krieg, Andreas
    Stoecklein, Nikolas H.
    PLOS ONE, 2013, 8 (03):
  • [44] Impact of HER2 expression on EGFR-TKI treatment outcomes in lung tumors harboring EGFR mutations: A HER2-CS study subset analysis
    Ohashi, Kadoaki
    Ninomiya, Kiichiro
    Yoshioka, Hiroshige
    Bessho, Akihiro
    Shibayama, Takuo
    Aoe, Keisuke
    Ishikawa, Nobuhisa
    Kozuki, Toshiyuki
    Kawai, Haruyuki
    Kuyama, Shoichi
    Miyoshi, Seigo
    Fujitaka, Kazunori
    Obata, Hideto
    Tsubata, Yukari
    Awaya, Yoshikazu
    Inoue, Masaaki
    Inoue, Koji
    Horita, Naokatsu
    Yanai, Hiroyuki
    Hotta, Katsuyuki
    Kiura, Katsuyuki
    LUNG CANCER, 2020, 150 : 83 - 89
  • [45] Epidermal growth factor receptor (EGFR) status in primary colorectal tumors does not correlate with EGFR expression in related metastatic sites: Implications for treatment with EGFR-targeted monoclonal antibodies
    Scartozzi, M
    Bearzi, I
    Berardi, R
    Mandolesi, A
    Fabris, G
    Cascinu, S
    JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (23) : 4772 - 4778
  • [46] Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel
    Sawai, Ayana
    Chandarlapaty, Sarat
    Greulich, Heidi
    Gonen, Mithat
    Ye, Qing
    Arteaga, Carlos L.
    Sellers, William
    Rosen, Neal
    Solit, David B.
    CANCER RESEARCH, 2008, 68 (02) : 589 - 596
  • [47] Influence of mRNA expression of epiregulin and amphiregulin on outcome of patients with metastatic colorectal cancer treated with 5-FU/LV plus irinotecan or irinotecan plus oxaliplatin as first-line treatment (FIRE 1-trial)
    Stahler, A.
    Heinemann, V.
    Giessen-Jung, C.
    Crispin, A.
    Schalhorn, A.
    Stintzing, S.
    von Weikersthal, L. Fischer
    Vehling-Kaiser, U.
    Stauch, M.
    Quietzsch, D.
    Held, S.
    von Einem, J. C.
    Holch, J.
    Neumann, J.
    Kirchner, T.
    Jung, A.
    Modest, D. P.
    INTERNATIONAL JOURNAL OF CANCER, 2016, 138 (03) : 739 - 746
  • [48] Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation
    Sofía del Carmen
    Luís Antonio Corchete
    Ruth Gervas
    Alba Rodriguez
    María Garcia
    José Antonio Álcazar
    Jacinto García
    Oscar Bengoechea
    Luis Muñoz-Bellvis
    José María Sayagués
    Mar Abad
    Scientific Reports, 10
  • [49] Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation
    del Carmen, Sofia
    Antonio Corchete, Luis
    Gervas, Ruth
    Rodriguez, Alba
    Garcia, Maria
    Antonio Alcazar, Jose
    Garcia, Jacinto
    Bengoechea, Oscar
    Munoz-Bellvis, Luis
    Maria Sayagues, Jose
    Abad, Mar
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [50] Rapamycin-insensitive companion of mTOR (RICTOR) amplification defines a subset of advanced gastric cancer and is sensitive to AZD2014-mediated mTORC1/2 inhibition
    Kim, S. T.
    Kim, S. Y.
    Klempner, S. J.
    Yoon, J.
    Kim, N.
    Ahn, S.
    Bang, H.
    Kim, K. -M.
    Park, W.
    Park, S. H.
    Park, J. O.
    Park, Y. S.
    Lim, H. Y.
    Lee, S. H.
    Park, K.
    Kang, W. K.
    Lee, J.
    ANNALS OF ONCOLOGY, 2017, 28 (03) : 547 - 554