Background: To evaluate the clinical safety and efficacy of implanted Ferrara intrastromal corneal ring segments in a large sample of patients with ectatic corneal disease. Design: Retrospective, consecutive case series. Samples: A total of 1073 eyes of 810 patients consecutively operated from January 2006 to July 2008 were evaluated. Methods: Two groups were created according to the type of ring implanted: Group 1 patients implanted with the 160 degrees of arc ring and Group 2 patients implanted with the 210 degrees of arc ring. Main Outcome Measures: Uncorrected visual acuity, best-corrected visual acuity, keratometry, asphericity and pachymetry at the thinnest point of the cornea. All patients were evaluated using a corneal tomography (Pentacam, Oculus, Inc., Lynnwood, WA, USA). Results: For Group 1 patients, uncorrected visual acuity increased to 20/80, best-corrected visual acuity increased to 20/40, asphericity decreased to -0.35, spherical equivalent decreased to -2.26 D and keratometry decreased to 45.72 D (P < 0.001 for each compared with preoperative values). For Group 2 patients, uncorrected visual acuity increased to 20/130, best-corrected visual acuity increased to 20/60, asphericity decreased to -0.56, spherical equivalent decreased to -4.14 D and keratometry decreased to 48.10 D (P < 0.001 for each compared with preoperative values). The 210 degrees intrastromal corneal ring segments reduced keratometry and asphericity more than the 160 degrees intrastromal corneal ring segments did. The complication rate was 3.82%. Conclusions: Ferrara intrastromal corneal ring segments implantation is safe and effective and has a low complication rate. It can effectively reduce the corneal steepening and improve uncorrected visual acuity and best-corrected visual acuity in patients with keratoconus.