Protein expression changes in cells inoculated with Equine Influenza Virus: antibody microarray analysis

被引:0
|
作者
Rozek, W. [1 ]
Kwasnik, M. [1 ]
Zmudzinski, J. F. [1 ]
机构
[1] Natl Inst Vet Res, Dept Virol, PL-24100 Pulawy, Poland
来源
POLISH JOURNAL OF VETERINARY SCIENCES | 2013年 / 16卷 / 04期
关键词
equine influenza; influenza; horses; antibody microarrays; proteomics; CYTOCHROME-C RELEASE; APOPTOSIS; DEATH; GENE; REPLICATION; ACTIVATION; BCL-X(L); KINASE; BCL-2;
D O I
10.2478/pjvs-2013-0094
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Changes in the level of cellular proteins in cells inoculated with equine influenza virus H7N7 and H3N8 were studied with microarray technique. H3N8 induced pro-apoptotic proteins while H7N7 induced both pro- as well as anti-apoptotic factors. The higher level of some cytoskeleton components and proteins involved in the protein quality control was recorded. Relatively high number of proteins involved in the regulation of transcription was down-regulated. The pattern of changes observed for H7N7 and H3N8 may reflect differences in the biological properties of both serotypes.
引用
收藏
页码:663 / 669
页数:7
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