New α-Pyridones with Quorum-Sensing Inhibitory Activity from Diversity-Enhanced Extracts of a Streptomyces sp Derived from Marine Algae

被引：44
|
作者：
Du, Yuqi [1 ]
Sun, Jian [1 ]
Gong, Qianhong [1 ]
Wang, Yi [1 ]
Fu, Peng [1 ]
Zhu, Weiming [1 ,2 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China
[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266003, Peoples R China
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2018年 / 66卷 / 08期
关键词：
pyridone; QS-inhibition; diversity-enhanced extracts; Streptomyces sp; Enteromorpha prolifera; NATURAL-PRODUCTS; SP OUCMDZ-3434; DERIVATIVES; FUNGUS; AGENTS; POLYSIPHONIA; POLYKETIDES; METABOLITES; UNIT;
D O I：
10.1021/acs.jafc.7b05330
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
Four new alpha-pyrones (1-4) and eight known analogues (5-12) were identified from the secondary metabolites of Streptomyces sp. OUCMDZ-3436 derived from the marine green algae Enteromorpha prolifera. Seven new alpha-pyridones (14-20) were constructed by diversity-oriented synthesis, which has been an effective approach to expanding the chemical space of natural-product-like compounds. Compounds 16, 17, 19, and 20 were found to have inhibitory effect on the gene expression controlled by quorum sensing in Pseudomonas aeruginosa QSIS-lasI.
引用
收藏
页码：1807 / 1812
页数：6
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