New α-Pyridones with Quorum-Sensing Inhibitory Activity from Diversity-Enhanced Extracts of a Streptomyces sp Derived from Marine Algae

被引：44

作者：

Du, Yuqi ^{[1
]}

Sun, Jian ^{[1
]}

Gong, Qianhong ^{[1
]}

Wang, Yi ^{[1
]}

Fu, Peng ^{[1
]}

Zhu, Weiming ^{[1
,2
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266003, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2018年 / 66卷 / 08期

关键词：

pyridone; QS-inhibition; diversity-enhanced extracts; Streptomyces sp; Enteromorpha prolifera; NATURAL-PRODUCTS; SP OUCMDZ-3434; DERIVATIVES; FUNGUS; AGENTS; POLYSIPHONIA; POLYKETIDES; METABOLITES; UNIT;

D O I：

10.1021/acs.jafc.7b05330

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Four new alpha-pyrones (1-4) and eight known analogues (5-12) were identified from the secondary metabolites of Streptomyces sp. OUCMDZ-3436 derived from the marine green algae Enteromorpha prolifera. Seven new alpha-pyridones (14-20) were constructed by diversity-oriented synthesis, which has been an effective approach to expanding the chemical space of natural-product-like compounds. Compounds 16, 17, 19, and 20 were found to have inhibitory effect on the gene expression controlled by quorum sensing in Pseudomonas aeruginosa QSIS-lasI.

引用

页码：1807 / 1812

页数：6

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