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A red-emitting naphthofluorescein-based fluorescent probe for selective detection of hydrogen peroxide in living cells

被引：75
|
作者：
Albers, Aaron E. [1 ]
Dickinson, Bryan C. [1 ]
Miller, Evan W. [1 ]
Chang, Christopher J. [1 ]
机构：
[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 22期
关键词：
Fluorescent probe; Hydrogen peroxide; Naphthofluorescein; Flow cytometry; Near infrared;
D O I：
10.1016/j.bmcl.2008.08.035
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We report the synthesis, properties, and cellular application of Naphtho-Peroxyfluor-1 (NPF1), a new fluorescent indicator for hydrogen peroxide based on a red-emitting naphthofluorescein platform. Owing to its boronate cages, NPF1 features high selectivity for hydrogen peroxide over a panel of biologically relevant reactive oxygen species (ROS), including superoxide and nitric oxide, as well as excitation and emission profiles in the far-red region of the visible spectrum (>600 nm). Flow cytometry experiments in RAW264.7 macrophages establish that NPF1 can report changes in peroxide levels in living cells. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5948 / 5950
页数：3
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