A red-emitting naphthofluorescein-based fluorescent probe for selective detection of hydrogen peroxide in living cells

被引：74
|
作者：
Albers, Aaron E. [1 ]
Dickinson, Bryan C. [1 ]
Miller, Evan W. [1 ]
Chang, Christopher J. [1 ]
机构：
[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 22期
关键词：
Fluorescent probe; Hydrogen peroxide; Naphthofluorescein; Flow cytometry; Near infrared;
D O I：
10.1016/j.bmcl.2008.08.035
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We report the synthesis, properties, and cellular application of Naphtho-Peroxyfluor-1 (NPF1), a new fluorescent indicator for hydrogen peroxide based on a red-emitting naphthofluorescein platform. Owing to its boronate cages, NPF1 features high selectivity for hydrogen peroxide over a panel of biologically relevant reactive oxygen species (ROS), including superoxide and nitric oxide, as well as excitation and emission profiles in the far-red region of the visible spectrum (>600 nm). Flow cytometry experiments in RAW264.7 macrophages establish that NPF1 can report changes in peroxide levels in living cells. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5948 / 5950
页数：3
相关论文
共 50 条
  • [21] A highly selective ratiometric visual and red-emitting fluorescent dual-channel probe for imaging fluoride anions in living cells
    Zhu, Baocun
    Kan, He
    Liu, Jingkai
    Liu, Hanging
    Wei, Qin
    Du, Bin
    BIOSENSORS & BIOELECTRONICS, 2014, 52 : 298 - 303
  • [22] A red-emitting fluorescent probe for biothiols detection with a large Stokes shift
    Qi, Fengpei
    Liu, Xingjiang
    Yang, Lei
    Yang, Liu
    Chen, Wenqiang
    Song, Xiangzhi
    TETRAHEDRON, 2016, 72 (44) : 6909 - 6913
  • [23] A mitochondria-targeted red-emitting probe for imaging hydrogen sulfide in living cells and zebrafish
    Ismail, Ismail
    Wang, Dan
    Wang, Dawei
    Niu, Cuili
    Huang, Haojie
    Yi, Long
    Xi, Zhen
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2019, 17 (13) : 3389 - 3395
  • [24] A novel ratiometric fluorescent probe for rapid detection of hydrogen peroxide in living cells
    Hu, Linan
    Liu, Jiayi
    Zhang, Jie
    Zhang, Hailiang
    Xu, Pengfei
    Chen, Zhu
    Xiao, Enhua
    RSC ADVANCES, 2019, 9 (67) : 39532 - 39535
  • [25] A novel fluorescent probe for selective detection of hydrogen sulfide in living cells
    Peng, Siqi
    Zhong, Tianya
    Guo, Tiantong
    Shu, Dehua
    Meng, Defen
    Liu, Haoran
    Guo, Dongcai
    NEW JOURNAL OF CHEMISTRY, 2018, 42 (07) : 5185 - 5192
  • [26] Two-photon fluorescent probe for hydrogen sulfide based on a red-emitting benzocoumarin dye
    Ryu, Hye Gun
    Singha, Subhankar
    Jun, Yong Woong
    Reo, Ye Jin
    Ahn, Kyo Han
    TETRAHEDRON LETTERS, 2018, 59 (01) : 49 - 53
  • [27] A novel isophorone-based red-emitting fluorescent probe for selective detection of sulfide anions in water for in vivo imaging
    Huo, Fangjun
    Zhang, Yaqiong
    Ning, Peng
    Meng, Xiangming
    Yin, Caixia
    JOURNAL OF MATERIALS CHEMISTRY B, 2017, 5 (15) : 2798 - 2803
  • [28] A red emitting fluorescent probe for sensitively monitoring hydrogen polysulfides in living cells and zebrafish
    Li, Wenxiu
    Zhou, Simin
    Zhang, Liangliang
    Yang, Zhengmin
    Chen, Hua
    Chen, Wenqiang
    Qin, Jiangke
    Shen, Xingcan
    Zhao, Shulin
    SENSORS AND ACTUATORS B-CHEMICAL, 2019, 284 : 30 - 35
  • [29] Lysosome-targetable red-emitting ratiometric fluorescent probe for hypobromous acid imaging in living cells
    Qu, Wangbo
    Li, Kaibin
    Han, Deman
    Zhong, Xinxin
    Chen, Caixia
    Liang, Xiuxia
    Liu, Heng
    SENSORS AND ACTUATORS B-CHEMICAL, 2019, 297
  • [30] A red emitting fluorescent probe for imaging mitochondrial hydrogen polysulfide in living cells and tissues
    Meng, Wenqi
    Shi, Wenwen
    Chen, Yongchun
    Zhang, Hao
    Zhao, Jie
    Li, Zhenjiang
    Xiao, Kai
    SENSORS AND ACTUATORS B-CHEMICAL, 2019, 281 : 871 - 877
12345