Targeted Therapy for Breast Cancer Stem Cells by Liposomal Delivery of siRNA against Fibronectin EDB

被引：30
|
作者：
Sun, Yujin [1 ,2 ]
Kim, Hoe Suk [1 ]
Saw, Phei Er [3 ]
Jon, Sangyong [3 ]
Moon, Woo Kyung [1 ]
机构：
[1] Seoul Natl Univ Hosp, Dept Radiol, Seoul 110744, South Korea
[2] Yanbian Univ Hosp, Dept Radiol, Yanji 133000, Jilin Province, Peoples R China
[3] Korea Adv Inst Sci & Technol, Taejon 305701, South Korea
来源：
ADVANCED HEALTHCARE MATERIALS | 2015年 / 4卷 / 11期
关键词：
aptides; breast cancer; stem cells; fibronectin; liposomes; RNA; targeted cancer therapy; INITIATING CELLS; NANOPARTICLES; ANGIOGENESIS; EXPRESSION; RESISTANCE; CARCINOMA; ADHESION; MARKER; DOMAIN;
D O I：
10.1002/adhm.201500190
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Targeted therapy for breast cancer stem cell (BCSC): A novel liposomal system (APTEDB-LS-siRNAEDB) that enables simultaneous targeting and knockdown of extra domain B of fibronectin (EDB-FN) shows potent therapeutic efficacy in the BCSC-derived tumors in vivo. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1675 / 1680
页数：6
相关论文
共 50 条
  • [41] Drug resistant breast and colon cancer stem cells: Targeted approach for stem cell therapy
    Telang, Nitin T.
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018, 42 : S6 - S6
  • [42] EpCAM-antibody-conjugated polymersomes for cancer stem cells-targeted delivery of anticancer drug and siRNA
    Chen, Jing
    Liu, Qiuming
    Du, Jianzhong
    JOURNAL OF CONTROLLED RELEASE, 2017, 259 : E60 - E61
  • [43] Mesenchymal stem cells: A promising targeted-delivery vehicle in cancer gene therapy
    Hu, Yu-Lan
    Fu, Ying-Hua
    Tabata, Yasuhiko
    Gao, Jian-Qing
    JOURNAL OF CONTROLLED RELEASE, 2010, 147 (02) : 154 - 162
  • [44] Targeted delivery of liposomal chemoimmunotherapy for cancer treatment
    Liu, Yusheng
    Han, Joonsu
    Bo, Yang
    Bhatta, Rimsha
    Wang, Hua
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [45] Cancer stem cells and strategies for targeted drug delivery
    Cao, Jin
    Bhatnagar, Shubhmita
    Wang, Jiawei
    Qi, Xueyong
    Prabha, Swayam
    Panyam, Jayanth
    DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2021, 11 (05) : 1779 - 1805
  • [46] Targeted Delivery of Therapeutics to Urological Cancer Stem Cells
    Liu, Qiang
    Gu, Jian
    Zhang, E.
    He, Lili
    Yuan, Zhi-Xiang
    CURRENT PHARMACEUTICAL DESIGN, 2020, 26 (17) : 2038 - 2056
  • [47] Nanomaterials for targeted drug delivery to cancer stem cells
    Orza, Anamaria
    Casciano, Daniel
    Biris, Alexandru
    DRUG METABOLISM REVIEWS, 2014, 46 (02) : 191 - 206
  • [48] Cancer stem cells and strategies for targeted drug delivery
    Jin Cao
    Shubhmita Bhatnagar
    Jiawei Wang
    Xueyong Qi
    Swayam Prabha
    Jayanth Panyam
    Drug Delivery and Translational Research, 2021, 11 : 1779 - 1805
  • [49] Targeted siRNA delivery to myeloid precursor cells
    Beyerle, A.
    Rueger, R.
    Scholz, A.
    Kontermann, R.
    Heidenreich, O.
    KLINISCHE PADIATRIE, 2011, 223 (03): : 200 - 200
  • [50] Targeted delivery of siRNA to macrophages and microglia cells
    Swamy, Manjunath N.
    JOURNAL OF NEUROVIROLOGY, 2010, 16 : 85 - 85
12345