Targeted Therapy for Breast Cancer Stem Cells by Liposomal Delivery of siRNA against Fibronectin EDB

被引：30
|
作者：
Sun, Yujin [1 ,2 ]
Kim, Hoe Suk [1 ]
Saw, Phei Er [3 ]
Jon, Sangyong [3 ]
Moon, Woo Kyung [1 ]
机构：
[1] Seoul Natl Univ Hosp, Dept Radiol, Seoul 110744, South Korea
[2] Yanbian Univ Hosp, Dept Radiol, Yanji 133000, Jilin Province, Peoples R China
[3] Korea Adv Inst Sci & Technol, Taejon 305701, South Korea
来源：
ADVANCED HEALTHCARE MATERIALS | 2015年 / 4卷 / 11期
关键词：
aptides; breast cancer; stem cells; fibronectin; liposomes; RNA; targeted cancer therapy; INITIATING CELLS; NANOPARTICLES; ANGIOGENESIS; EXPRESSION; RESISTANCE; CARCINOMA; ADHESION; MARKER; DOMAIN;
D O I：
10.1002/adhm.201500190
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Targeted therapy for breast cancer stem cell (BCSC): A novel liposomal system (APTEDB-LS-siRNAEDB) that enables simultaneous targeting and knockdown of extra domain B of fibronectin (EDB-FN) shows potent therapeutic efficacy in the BCSC-derived tumors in vivo. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1675 / 1680
页数：6
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