An Efficient Domino Approach for the Synthesis of Multisubstituted Pyrroles via Gold/Silver-Catalyzed Amination/Cycloisomerization of (Z)-2-En-4-yn-1-ols

被引：98

作者：

Lu, Yuhua ^{[1
,2
]}

Fu, Xiaoping ^{[1
]}

Chen, Haoyi ^{[1
]}

Du, Xiangwei ^{[1
]}

Jia, Xueshun ^{[2
]}

Liu, Yuanhong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

[2] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

amination; cycloisomerization; (Z)-enynols; gold catalysis; pyrroles; INTRAMOLECULAR HYDROAMINATION; SUBSTITUTED PYRROLES; INTERMOLECULAR HYDROAMINATION; DIRECT AMINATION; REGIOSELECTIVE SYNTHESIS; HOMOGENEOUS CATALYSIS; ORGANIC-SYNTHESIS; GOLD CATALYSIS; ALCOHOLS; ALKYNES;

D O I：

10.1002/adsc.200800490

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient and one-pot synthesis of multisubstituted pyrroles with high diversity and in a regioselective manner from the reactions of suitably substituted (Z)-enynols with amines or sulfonamides under mild reaction conditions has been developed. This synthesis was realized via a cascade process in the presence of gold/silver (Au/Ag) or boron trifluoride center dot etherate/gold/silver (BF3 center dot Et2O/Au/Ag) catalysts, which could catalyze amination and cycloisomerization reactions in the same vessel.

引用

页码：129 / 134

页数：6

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