Optogenetic probing of mitochondrial damage responses

被引：10

作者：

Yang, Wei Yuan ^{[1
,2
]}

机构：

[1] Acad Sinica, Inst Biol Chem, TW-115 Taipei, Taiwan

[2] Natl Taiwan Univ, Coll Life Sci, Inst Biochem Sci, Taipei 10764, Taiwan

来源：

MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE | 2015年 / 1350卷

关键词：

Parkin; mitochondria; autophagy; Parkinson disease; mitophagy; optogenetics; photochemical control; photosensitizer; quality control; PARTIAL CELL IRRADIATION; PARKIN; MITOPHAGY; AUTOPHAGY; PROTEIN; LASER; PHOTOSENSITIZER; INACTIVATION; DISEASE; PINK1;

D O I：

10.1111/nyas.12818

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

It is now possible to functionally impair mitochondria through light illumination with high specificity. These optogenetic tools permit precise control on the timing, location, and extent of mitochondrial damage within a cell population with subcellular resolution, allowing quantitative probing of the various types of mitochondrial damage responses within cells. This approach can generally be extended toward the probing of other organelle damage responses.

引用

页码：48 / 51

页数：4

共 50 条

[31] Heterogeneous brain region-specific responses to astrocytic mitochondrial DNA damage in mice
Ayala, Daniela A.
Matarazzo, Anthony
Seaberg, Bonnie L.
Patel, Misha
Tijerina, Eliana
Matthews, Camryn
Bizi, Gabriel
Brown, Ashton
Ta, Alan
Rimer, Mendell
Srinivasan, Rahul
SCIENTIFIC REPORTS, 2024, 14 (01):
[32] PROBING STRUCTURE AND MOTION OF THE MITOCHONDRIAL CYTOCHROMES
DIXIT, BPSN
VANDERKOOI, JM
CURRENT TOPICS IN BIOENERGETICS, 1984, 13 : 159 - 202
[33] Probing polar bodies for mitochondrial DNA
Lewis, R
SCIENTIST, 2000, 14 (12): : 24 - 24
[34] Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance
Berry, Brandon J.
Trewin, Adam J.
Milliken, Alexander S.
Baldzizhar, Aksana
Amitrano, Andrea M.
Lim, Yunki
Kim, Minsoo
Wojtovich, Andrew P.
EMBO REPORTS, 2020, 21 (04)
[35] Mitochondrial damage control
Asa Abeliovich
Nature, 2010, 463 : 744 - 745
[36] Probing radiation damage at the molecular level
Mason, N. J.
Smialek, M. A.
Moore, S. A.
Folkard, M.
Hoffmann, S. V.
PHYSICS OF IONIZED GASES, 2006, 876 : 3 - +
[37] Optogenetic Probing of Fast Glutamatergic Transmission from Hypocretin/Orexin to Histamine Neurons In Situ
Schoene, Cornelia
Cao, Zhen Fang Huang
Apergis-Schoute, John
Adamantidis, Antoine
Sakurai, Takeshi
Burdakov, Denis
JOURNAL OF NEUROSCIENCE, 2012, 32 (36): : 12437 - 12443
[38] Akt kinase inhibition facilitates p53 protein-dependent mitochondrial damage responses after DNA damage
Franke, Thomas
Shostak, Gregory
Grabham, Peter
FASEB JOURNAL, 2012, 26
[39] Effects of cyclosporin H on airway inflammatory responses induced by mitochondrial damage associated molecular patterns
Li, Min
Zhang, Xue
Jia, Liuqun
Long, Hongyu
Shen, Yongchun
Pang, Caishuang
Wen, Fuqiang
EUROPEAN RESPIRATORY JOURNAL, 2014, 44
[40] Probing the Activation Mechanism of BAK in Mitochondrial Apoptosis
Tesney, Michala
Singh, Geetika
Guibao, Cristina
Moldoveanu, Tudor
FASEB JOURNAL, 2017, 31

← 1 2 3 4 5 →