Optogenetic probing of mitochondrial damage responses

被引：10
|
作者：
Yang, Wei Yuan [1 ,2 ]
机构：
[1] Acad Sinica, Inst Biol Chem, TW-115 Taipei, Taiwan
[2] Natl Taiwan Univ, Coll Life Sci, Inst Biochem Sci, Taipei 10764, Taiwan
来源：
MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE | 2015年 / 1350卷
关键词：
Parkin; mitochondria; autophagy; Parkinson disease; mitophagy; optogenetics; photochemical control; photosensitizer; quality control; PARTIAL CELL IRRADIATION; PARKIN; MITOPHAGY; AUTOPHAGY; PROTEIN; LASER; PHOTOSENSITIZER; INACTIVATION; DISEASE; PINK1;
D O I：
10.1111/nyas.12818
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
It is now possible to functionally impair mitochondria through light illumination with high specificity. These optogenetic tools permit precise control on the timing, location, and extent of mitochondrial damage within a cell population with subcellular resolution, allowing quantitative probing of the various types of mitochondrial damage responses within cells. This approach can generally be extended toward the probing of other organelle damage responses.
引用
收藏
页码：48 / 51
页数：4
相关论文
共 50 条
  • [21] Mitochondrial light switches: optogenetic approaches to control metabolism
    Berry, Brandon J.
    Wojtovich, Andrew P.
    FEBS JOURNAL, 2020, 287 (21) : 4544 - 4556
  • [22] Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures
    Zhang, Feng
    Gradinaru, Viviana
    Adamantidis, Antoine R.
    Durand, Remy
    Airan, Raag D.
    de Lecea, Luis
    Deisseroth, Karl
    NATURE PROTOCOLS, 2010, 5 (03) : 439 - 456
  • [23] Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures
    Feng Zhang
    Viviana Gradinaru
    Antoine R Adamantidis
    Remy Durand
    Raag D Airan
    Luis de Lecea
    Karl Deisseroth
    Nature Protocols, 2010, 5 : 439 - 456
  • [24] Probing Yeast Polarity with Acute, Reversible, Optogenetic Inhibition of Protein Function
    Jost, Anna Payne-Tobin
    Weiner, Orion D.
    ACS SYNTHETIC BIOLOGY, 2015, 4 (10): : 1077 - 1085
  • [25] Genetic and Optogenetic Strategies for Probing the Complex Output Pathways of the Lateral Habenula
    Turner, Eric
    Hsu, Yun-Wei
    Quina, Lely
    NEUROPSYCHOPHARMACOLOGY, 2015, 40 : S306 - S307
  • [26] Probing mitochondrial metabolism in vivo
    McElroy, Gregory S.
    Chandel, Navdeep S.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (01) : 20 - 22
  • [27] Probing mitochondrial membrane potential
    Arnaud, Celia
    CHEMICAL & ENGINEERING NEWS, 2020, 98 (31) : 10 - 10
  • [28] Damage, Healing, and Remodeling in Optogenetic Skeletal Muscle Bioactuators
    Raman, Ritu
    Grant, Lauren
    Seo, Yongbeom
    Cvetkovic, Caroline
    Gapinske, Michael
    Palasz, Alexandra
    Dabbous, Howard
    Kong, Hyunjoon
    Pinera, Pablo Perez
    Bashir, Rashid
    ADVANCED HEALTHCARE MATERIALS, 2017, 6 (12)
  • [29] Probing the Damage Zone at Parkfield
    Delorey, Andrew A.
    Guyer, Robert A.
    Bokelmann, Gotz H. R.
    Johnson, Paul A.
    GEOPHYSICAL RESEARCH LETTERS, 2021, 48 (13)
  • [30] Behavior Responses to Chemical and Optogenetic Stimuli in Drosophila Larvae
    Clark, David A.
    Odell, Seth R.
    Armstrong, Joanna M.
    Turcotte, Mariah
    Kohler, Donovan
    Mathis, America
    Schmidt, Deena R.
    Mathew, Dennis
    FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2018, 12
12345