Optogenetic probing of mitochondrial damage responses

被引：10
|
作者：
Yang, Wei Yuan [1 ,2 ]
机构：
[1] Acad Sinica, Inst Biol Chem, TW-115 Taipei, Taiwan
[2] Natl Taiwan Univ, Coll Life Sci, Inst Biochem Sci, Taipei 10764, Taiwan
来源：
MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE | 2015年 / 1350卷
关键词：
Parkin; mitochondria; autophagy; Parkinson disease; mitophagy; optogenetics; photochemical control; photosensitizer; quality control; PARTIAL CELL IRRADIATION; PARKIN; MITOPHAGY; AUTOPHAGY; PROTEIN; LASER; PHOTOSENSITIZER; INACTIVATION; DISEASE; PINK1;
D O I：
10.1111/nyas.12818
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
It is now possible to functionally impair mitochondria through light illumination with high specificity. These optogenetic tools permit precise control on the timing, location, and extent of mitochondrial damage within a cell population with subcellular resolution, allowing quantitative probing of the various types of mitochondrial damage responses within cells. This approach can generally be extended toward the probing of other organelle damage responses.
引用
收藏
页码：48 / 51
页数：4
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