Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain

被引：3
|
作者：
Ryder, Edward [1 ]
Wong, Kim [1 ]
Gleeson, Diane [1 ]
Keane, Thomas M. [1 ]
Sethi, Debarati [1 ]
Vyas, Sapna [1 ]
Wardle-Jones, Hannah [1 ]
Bussell, James N. [1 ]
Houghton, Richard [1 ]
Salisbury, Jennifer [1 ]
Harvey, Nina [1 ]
Adams, David J. [1 ]
Ramirez-Solis, Ramiro [1 ]
机构：
[1] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
来源：
GENESIS | 2013年 / 51卷 / 07期
基金：
英国惠康基金;
关键词：
mouse; genome sequencing; genetics; transgenics; mammalian; genomics; RESOURCE;
D O I：
10.1002/dvg.22398
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N-Tyr(cWTSI)). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background. genesis 51:523-528. (c) 2013 Wiley Periodicals, Inc.
引用
收藏
页码：523 / 528
页数：6
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