Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain

被引：3

作者：

Ryder, Edward ^{[1
]}

Wong, Kim ^{[1
]}

Gleeson, Diane ^{[1
]}

Keane, Thomas M. ^{[1
]}

Sethi, Debarati ^{[1
]}

Vyas, Sapna ^{[1
]}

Wardle-Jones, Hannah ^{[1
]}

Bussell, James N. ^{[1
]}

Houghton, Richard ^{[1
]}

Salisbury, Jennifer ^{[1
]}

Harvey, Nina ^{[1
]}

Adams, David J. ^{[1
]}

Ramirez-Solis, Ramiro ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England

来源：

GENESIS | 2013年 / 51卷 / 07期

基金：

英国惠康基金;

关键词：

mouse; genome sequencing; genetics; transgenics; mammalian; genomics; RESOURCE;

D O I：

10.1002/dvg.22398

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N-Tyr(cWTSI)). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background. genesis 51:523-528. (c) 2013 Wiley Periodicals, Inc.

引用

页码：523 / 528

页数：6

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