The PET image quality of overweight patients and patients who receive low injected doses deteriorates because of increases in statistical noise. The purpose of this study was to investigate the benefits of the point-spread function (PSF) and time-of-flight (TOF) for PET/CT image quality in such patients. Methods: The PET images were reconstructed using the baseline ordered-subsets expectation-maximization algorithm (OSEM), OSEM + PSF, OSEM + TOF, and OSEM + PSF + TOF. In the phantom study, we used a National Electrical Manufacturers Association body phantom with different radioactivity concentrations and analyzed image quality using the coefficient of variance in the background (CVphantom). In the clinical study, we retrospectively studied 39 patients who underwent clinical F-18-FDG PET/CT. The patients were classified into groups based on body mass index and injected dose. Image quality was evaluated using the CV in the liver (CVliver). Results: In the phantom study, PSF and TOF improved the CVphantom, especially in low-activity models. Among all of the reconstructions, the best CVphantom was obtained with OSEM + PSF + TOF. In the clinical study, the CVliver of the low-dose group with OSEM + PSF + TOF was comparable to that of the high-dose group with conventional OSEM. Conclusions: Point-spread function and TOF improved PET/CT image quality for overweight patients who received a lower injected dose. Therefore, the use of PSF and TOF is suggested to maintain the image quality of such patients without extending scanning times. It is greatly beneficial to obtain sufficient image quality for larger patients, especially in delivery institutions where the injection dose cannot be easily increased.
机构:Kyushu Univ, Div Med Quantum Sci, Dept Hlth Sci, Grad Sch Med Sci,Higashi Ku, Fukuoka 8128582, Japan
Akamatsu, Go
Ishikawa, Kaori
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机构:Kyushu Univ, Div Med Quantum Sci, Dept Hlth Sci, Grad Sch Med Sci,Higashi Ku, Fukuoka 8128582, Japan
Ishikawa, Kaori
Mitsumoto, Katsuhiko
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机构:Kyushu Univ, Div Med Quantum Sci, Dept Hlth Sci, Grad Sch Med Sci,Higashi Ku, Fukuoka 8128582, Japan
Mitsumoto, Katsuhiko
Taniguchi, Takafumi
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机构:Kyushu Univ, Div Med Quantum Sci, Dept Hlth Sci, Grad Sch Med Sci,Higashi Ku, Fukuoka 8128582, Japan
Taniguchi, Takafumi
Ohya, Nobuyoshi
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Kyushu Univ Hosp, Dept Med Technol, Fukuoka 812, JapanKyushu Univ, Div Med Quantum Sci, Dept Hlth Sci, Grad Sch Med Sci,Higashi Ku, Fukuoka 8128582, Japan
Ohya, Nobuyoshi
Baba, Shingo
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Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Fukuoka 8128582, JapanKyushu Univ, Div Med Quantum Sci, Dept Hlth Sci, Grad Sch Med Sci,Higashi Ku, Fukuoka 8128582, Japan
Baba, Shingo
Abe, Koichiro
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Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Fukuoka 8128582, JapanKyushu Univ, Div Med Quantum Sci, Dept Hlth Sci, Grad Sch Med Sci,Higashi Ku, Fukuoka 8128582, Japan
Abe, Koichiro
Sasaki, Masayuki
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Kyushu Univ, Div Med Quantum Sci, Dept Hlth Sci, Grad Sch Med Sci,Higashi Ku, Fukuoka 8128582, JapanKyushu Univ, Div Med Quantum Sci, Dept Hlth Sci, Grad Sch Med Sci,Higashi Ku, Fukuoka 8128582, Japan
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Capital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R China
Shang, Kun
Cui, Bixiao
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Capital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R China
Cui, Bixiao
Ma, Jie
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Capital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R China
Ma, Jie
Shuai, Dongmei
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Capital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R China
Shuai, Dongmei
Liang, Zhigang
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Capital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R China
Liang, Zhigang
Jansen, Floris
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GE Healthcare, Waukesha, WI USACapital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R China
Jansen, Floris
Zhou, Yun
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Johns Hopkins Univ, Dept Radiol, Baltimore, MD USACapital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R China
Zhou, Yun
Lu, Jie
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Capital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R China
Lu, Jie
Zhao, Guoguang
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Capital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R China
Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Nucl Med, 45 Changchunjie, Beijing 100053, Peoples R China