Benefits of Point-Spread Function and Time of Flight for PET/CT Image Quality in Relation to the Body Mass Index and Injected Dose

被引:19
|
作者
Akamatsu, Go [1 ]
Mitsumoto, Katsuhiko [1 ]
Ishikawa, Kaori [1 ]
Taniguchi, Takafumi [1 ]
Ohya, Nobuyoshi [2 ]
Baba, Shingo [3 ]
Abe, Koichiro [3 ]
Sasaki, Masayuki [1 ]
机构
[1] Kyushu Univ, Grad Sch Med Sci, Dept Hlth Sci, Fukuoka 8128582, Japan
[2] Kyushu Univ Hosp, Dept Med Technol, Fukuoka, Japan
[3] Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Fukuoka 8128582, Japan
基金
日本学术振兴会;
关键词
point-spread function; time-of-flight; image quality; BMI; injected dose; POSITRON-EMISSION-TOMOGRAPHY; LESION DETECTION; F-18-FDG PET/CT; PATIENT WEIGHT; SCAN DURATION; LUNG-CANCER; IMPACT; RECONSTRUCTION; PROTOCOLS; PERFORMANCE;
D O I
10.1097/RLU.0b013e31828da3bd
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The PET image quality of overweight patients and patients who receive low injected doses deteriorates because of increases in statistical noise. The purpose of this study was to investigate the benefits of the point-spread function (PSF) and time-of-flight (TOF) for PET/CT image quality in such patients. Methods: The PET images were reconstructed using the baseline ordered-subsets expectation-maximization algorithm (OSEM), OSEM + PSF, OSEM + TOF, and OSEM + PSF + TOF. In the phantom study, we used a National Electrical Manufacturers Association body phantom with different radioactivity concentrations and analyzed image quality using the coefficient of variance in the background (CVphantom). In the clinical study, we retrospectively studied 39 patients who underwent clinical F-18-FDG PET/CT. The patients were classified into groups based on body mass index and injected dose. Image quality was evaluated using the CV in the liver (CVliver). Results: In the phantom study, PSF and TOF improved the CVphantom, especially in low-activity models. Among all of the reconstructions, the best CVphantom was obtained with OSEM + PSF + TOF. In the clinical study, the CVliver of the low-dose group with OSEM + PSF + TOF was comparable to that of the high-dose group with conventional OSEM. Conclusions: Point-spread function and TOF improved PET/CT image quality for overweight patients who received a lower injected dose. Therefore, the use of PSF and TOF is suggested to maintain the image quality of such patients without extending scanning times. It is greatly beneficial to obtain sufficient image quality for larger patients, especially in delivery institutions where the injection dose cannot be easily increased.
引用
收藏
页码:407 / 412
页数:6
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