Study on magnetic gene transfer using HTS bulk magnet

被引：3
|
作者：
Nakagawa, Kota [1 ]
Ohaku, Yoshihiro [1 ]
Tamada, Junya [1 ]
Mishima, Fumihito [1 ]
Akiyama, Yoko [1 ]
Osako, Mariana Kiomy [2 ]
Nakagami, Hironori [2 ]
Nishijima, Shigehiro [1 ]
机构：
[1] Osaka Univ, Grad Sch Engn, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Med, Suita, Osaka 5650871, Japan
来源：
PHYSICA C-SUPERCONDUCTIVITY AND ITS APPLICATIONS | 2013年 / 494卷
关键词：
Magnetic gene transfer; HTS bulk magnet; Diffusion; Magnetite; DELIVERY;
D O I：
10.1016/j.physc.2013.04.072
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
This study aimed to realize local and high-efficient gene expression by suppressing the diffusion of ferromagnetic DNA carriers in a strong magnetic field generated by HTS bulk magnet. DNA-magnetite complexes were prepared as ferromagnetic DNA carrier and the magnetic gene transfer using the DNA carriers was examined. From the results of the simulation and the model experiment, it was shown that the particle diffusion was suppressed within 10 mm in diameter by the magnetic field at 20 mm above the HTS bulk magnet. The results of in vivo experiments showed that the amount of gene expression was significantly increased by magnetic field. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：262 / 264
页数：3
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