Synthesis of sterically hindered ketones from aldehydes via O-silyl oximes

被引：3
|
作者：
Kim, Joong-Gon [2 ]
Mishra, Mithilesh Kumar [1 ]
Jang, Doo Ok [1 ]
机构：
[1] Yonsei Univ, Dept Chem, Wonju 220710, South Korea
[2] Hanwha Chem R&D Ctr, Div Biotechnol, Taejon 305345, South Korea
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 27期
关键词：
Ketone; Aldehyde; Triethyl borane; O-triphenylsilylated oxime; CARBON RADICAL-ADDITION; ARYL KETONES; ASYMMETRIC-SYNTHESIS; CARBOXYLIC-ACIDS; RASPBERRY KETONE; BUILDING-BLOCKS; AMINO-ACIDS; ACYLATION; ETHER; MILD;
D O I：
10.1016/j.tetlet.2012.05.005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild and efficient method to synthesize sterically hindered ketones from aldehydes via O-silyl oximes was developed. Treatment of O-triphenylsilylated oximes with alkyl iodides in the presence of triethyl borane afforded the corresponding ketones. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3527 / 3529
页数：3
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