Synthesis of sterically hindered ketones from aldehydes via O-silyl oximes

被引：3

作者：

Kim, Joong-Gon ^{[2
]}

Mishra, Mithilesh Kumar ^{[1
]}

Jang, Doo Ok ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem, Wonju 220710, South Korea

[2] Hanwha Chem R&D Ctr, Div Biotechnol, Taejon 305345, South Korea

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 27期

关键词：

Ketone; Aldehyde; Triethyl borane; O-triphenylsilylated oxime; CARBON RADICAL-ADDITION; ARYL KETONES; ASYMMETRIC-SYNTHESIS; CARBOXYLIC-ACIDS; RASPBERRY KETONE; BUILDING-BLOCKS; AMINO-ACIDS; ACYLATION; ETHER; MILD;

D O I：

10.1016/j.tetlet.2012.05.005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient method to synthesize sterically hindered ketones from aldehydes via O-silyl oximes was developed. Treatment of O-triphenylsilylated oximes with alkyl iodides in the presence of triethyl borane afforded the corresponding ketones. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：3527 / 3529

页数：3

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