Polymer-Supported Well-Defined Metathesis Catalysts

A comprehensive summary of the achievements made in the chemistry of polymer-supported well-defined metathesis catalysts is presented. The monolithic disk-immobilized catalyst are used in various metathesis-based reactions such as RCM, ring-opening metathesis, and enzyme metathesis. The immobilization of first and second-generation Grubbs catalyst on poly(ethylene glycol) shows that PEG-bound second-generation catalyst display superior recyclability in RCM compared to the corresponding PEG-bound first-generation system. The annealing alternative concept for immobilization of a Grubbs-Hoveyda catalyst was reported and that supported catalyst was multiply used in the RCM of N,N-diallyl-N-tosylamide. A substituted unprotected chiral biphenyl subjected to ROMP in the presence of a crosslinker obtained enantiomeric excess in a series of asymmetric reactions similar to the parent and unsupported reactions.