Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis

被引：4

作者：

Li, Zhuo ^{[1
,2
]}

Hou, Xiaomin ^{[3
]}

Liu, Xuehua ^{[3
]}

Ma, Linlin ^{[3
]}

Tan, Jiewen ^{[1
,4
]}

机构：

[1] Guangzhou Xinhua Univ, Dept Rehabil Med, Guangzhou, Peoples R China

[2] Shenzhen Peoples Hosp, Hyperbar Oxygen Dept, Shenzhen, Peoples R China

[3] Capital Med Univ, Beijing Chaoyang Hosp, Hyperbar Oxygen Dept, Beijing, Peoples R China

[4] Guangzhou Xinhua Univ, Dept Rehabil Med, 19 Longdong Rd, Guangzhou 510520, Peoples R China

来源：

DOSE-RESPONSE | 2022年 / 20卷 / 04期

关键词：

proteomic; hyperbaric oxygen therapy; spinal cord injury; isobaric tags for relative and absolute quantification; RECOVERY; IMPROVES; EXPRESSION;

D O I：

10.1177/15593258221141579

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hyperbaric Oxygen Therapy (HBOT) has definitive therapeutic effects on spinal cord injury (SCI), but its mechanism of action is still unclear. Here, we've conducted a systemic proteomic analysis to identify differentially expressed proteins (DEPs) between SCI rats and HBOT + SCI rats. The function clustering analysis showed that the top enriched pathways of DEPs include oxygen transport activity, oxygen binding, and regulation of T cell proliferation. The results of functional and signal pathway analyses indicated that metabolic pathways, thermogenesis, LXR/RXR activation, acute phase response signaling, and the intrinsic prothrombin pathway in the SCI + HBOT group was higher than SCI group.

引用

页数：9

共 50 条

[31] Synergistic neuroprotective effects of hyperbaric oxygen and methylprednisolone following contusive spinal cord injury in rat
Ahmadi, Fahimeh
Zargari, Mehryar
Nasiry, Davood
Khalatbary, Ali Reza
JOURNAL OF SPINAL CORD MEDICINE, 2022, 45 (06): : 930 - 939
[32] Effects of hyperbaric oxygen therapy on postoperative recovery after incomplete cervical spinal cord injury
Zhang, Zhiwu
Li, Qian
Yang, Xiang
Li, Bin
Zhou, Yijun
Hu, Tianye
Yuan, Jiajun
Dong, Ping
SPINAL CORD, 2022, 60 (02) : 129 - 134
[33] Reshaping cortical connectivity in traumatic spinal cord injury: a novel effect of hyperbaric oxygen therapy
Francesco Marrosu
Stefano Mancosu
Gianluca Lai
Matteo Fraschini
Antonella Muroni
Matteo Demuru
Marco Monticone
Giovanni Defazio
Spinal Cord Series and Cases, 7
[34] Hyperbaric oxygen therapy combined with Schwann cell transplantation promotes spinal cord injury recovery
Chuan-gang Peng
Shu-quan Zhang
Min-fei Wu
Yang Lv
Dan-kai Wu
Qi Yang
Rui Gu
Neural Regeneration Research, 2015, 10 (09) : 1477 - 1482
[35] Reshaping cortical connectivity in traumatic spinal cord injury: a novel effect of hyperbaric oxygen therapy
Marrosu, Francesco
Mancosu, Stefano
Lai, Gianluca
Fraschini, Matteo
Muroni, Antonella
Demuru, Matteo
Monticone, Marco
Defazio, Giovanni
SPINAL CORD SERIES AND CASES, 2021, 7 (01)
[36] Hyperbaric oxygen therapy combined with Schwann cell transplantation promotes spinal cord injury recovery
Peng, Chuan-gang
Zhang, Shu-quan
Wu, Min-fei
Lv, Yang
Wu, Dan-kai
Yang, Qi
Gu, Rui
NEURAL REGENERATION RESEARCH, 2015, 10 (09) : 1477 - 1482
[37] Effects of hyperbaric oxygen therapy on postoperative recovery after incomplete cervical spinal cord injury
Zhiwu Zhang
Qian Li
Xiang Yang
Bin Li
Yijun Zhou
Tianye Hu
Jiajun Yuan
Ping Dong
Spinal Cord, 2022, 60 : 129 - 134
[38] Proteomic analysis of spinal cord tissue in a rat model of cancer-induced bone pain
Yang, Heyu
Wu, Ji
Zhen, Shuqing
Hu, Yindi
Li, Dai
Xie, Min
Zhu, Haili
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2022, 15
[39] Molecular Expression Profile of Changes in Rat Acute Spinal Cord Injury
Wang, Jun-Juan
Ye, Guo
Ren, Hao
An, Cheng-Rui
Huang, Lvxing
Chen, Hengyi
Zhang, Hui
Lin, Jun-Xin
Shen, Xilin
Heng, Boon Chin
Zhou, Jing
FRONTIERS IN CELLULAR NEUROSCIENCE, 2021, 15
[40] ACUTE EFFECTS OF HYPERBARIC-OXYGEN THERAPY ON LONG TRACT CONDUCTION IN SPINAL-CORD INJURY
HIGGINS, AC
NASHOLD, BS
NEUROSURGERY, 1981, 8 (04) : 494 - 494

← 1 2 3 4 5 →