Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis

被引：4
|
作者：
Li, Zhuo [1 ,2 ]
Hou, Xiaomin [3 ]
Liu, Xuehua [3 ]
Ma, Linlin [3 ]
Tan, Jiewen [1 ,4 ]
机构：
[1] Guangzhou Xinhua Univ, Dept Rehabil Med, Guangzhou, Peoples R China
[2] Shenzhen Peoples Hosp, Hyperbar Oxygen Dept, Shenzhen, Peoples R China
[3] Capital Med Univ, Beijing Chaoyang Hosp, Hyperbar Oxygen Dept, Beijing, Peoples R China
[4] Guangzhou Xinhua Univ, Dept Rehabil Med, 19 Longdong Rd, Guangzhou 510520, Peoples R China
来源：
DOSE-RESPONSE | 2022年 / 20卷 / 04期
关键词：
proteomic; hyperbaric oxygen therapy; spinal cord injury; isobaric tags for relative and absolute quantification; RECOVERY; IMPROVES; EXPRESSION;
D O I：
10.1177/15593258221141579
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Hyperbaric Oxygen Therapy (HBOT) has definitive therapeutic effects on spinal cord injury (SCI), but its mechanism of action is still unclear. Here, we've conducted a systemic proteomic analysis to identify differentially expressed proteins (DEPs) between SCI rats and HBOT + SCI rats. The function clustering analysis showed that the top enriched pathways of DEPs include oxygen transport activity, oxygen binding, and regulation of T cell proliferation. The results of functional and signal pathway analyses indicated that metabolic pathways, thermogenesis, LXR/RXR activation, acute phase response signaling, and the intrinsic prothrombin pathway in the SCI + HBOT group was higher than SCI group.
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页数：9
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