Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis

被引：4

作者：

Li, Zhuo ^{[1
,2
]}

Hou, Xiaomin ^{[3
]}

Liu, Xuehua ^{[3
]}

Ma, Linlin ^{[3
]}

Tan, Jiewen ^{[1
,4
]}

机构：

[1] Guangzhou Xinhua Univ, Dept Rehabil Med, Guangzhou, Peoples R China

[2] Shenzhen Peoples Hosp, Hyperbar Oxygen Dept, Shenzhen, Peoples R China

[3] Capital Med Univ, Beijing Chaoyang Hosp, Hyperbar Oxygen Dept, Beijing, Peoples R China

[4] Guangzhou Xinhua Univ, Dept Rehabil Med, 19 Longdong Rd, Guangzhou 510520, Peoples R China

来源：

DOSE-RESPONSE | 2022年 / 20卷 / 04期

关键词：

proteomic; hyperbaric oxygen therapy; spinal cord injury; isobaric tags for relative and absolute quantification; RECOVERY; IMPROVES; EXPRESSION;

D O I：

10.1177/15593258221141579

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hyperbaric Oxygen Therapy (HBOT) has definitive therapeutic effects on spinal cord injury (SCI), but its mechanism of action is still unclear. Here, we've conducted a systemic proteomic analysis to identify differentially expressed proteins (DEPs) between SCI rats and HBOT + SCI rats. The function clustering analysis showed that the top enriched pathways of DEPs include oxygen transport activity, oxygen binding, and regulation of T cell proliferation. The results of functional and signal pathway analyses indicated that metabolic pathways, thermogenesis, LXR/RXR activation, acute phase response signaling, and the intrinsic prothrombin pathway in the SCI + HBOT group was higher than SCI group.

引用

页数：9

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