A frameshift mutation in hepatocyte nuclear factor 1β cause diabetes by β cell dysfunction and renal dysfunction by abnormal nephron development

被引：0
|
作者：
Hattersley, AT
Bingham, C
Shepard, M
Allen, LI
Berry, P
Bulman, M
Frayling, TM
Ellard, S
机构：
来源：
DIABETES | 1999年 / 48卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
0140
引用
收藏
页码：A33 / A33
页数：1
相关论文
共 50 条
  • [41] Hepatic nuclear factor 1 alpha mutations result in beta-cell dysfunction
    Hattersley, AT
    Appleton, M
    Smith, SM
    Burrows, JA
    Ellard, S
    Frayling, T
    Bulman, M
    Clark, PM
    DIABETOLOGIA, 1997, 40 : 634 - 634
  • [42] A novel hepatocyte nuclear factor-1β (MODY-5) gene mutation in an Italian family with renal dysfunctions and early-onset diabetes
    Diabetologia, 2002, 45 (1) : 153 - 154
  • [43] A novel hepatocyte nuclear factor-1β (MODY-5) gene mutation in an Italian family with renal dysfunctions and early-onset diabetes
    Carbone, I
    Cotellessa, M
    Barella, C
    Minetti, C
    Ghiggeri, GM
    Caridi, G
    Perfumo, F
    Lorini, R
    DIABETOLOGIA, 2002, 45 (01) : 153 - 154
  • [44] Urinary Transforming Growth Factor β-1 as a Marker of Renal Dysfunction in Sickle Cell Disease
    Ghobrial, Emad E.
    Abdel-Aziz, Hanan A.
    Kaddah, Ahmed M.
    Mubarak, Nesma A.
    PEDIATRICS AND NEONATOLOGY, 2016, 57 (03): : 174 - 180
  • [45] The transcription factor SREBP-1c is instrumental in the development of β-cell dysfunction
    Wang, HY
    Maechler, P
    Antinozzi, PA
    Herrero, L
    Hagenfeldt-Johansson, KA
    Björklund, A
    Wollheim, CB
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (19) : 16622 - 16629
  • [46] Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha gene
    Gragnoli, C
    Lindner, T
    Cockburn, BN
    Kaisaki, PJ
    Gragnoli, F
    Marozzi, G
    Bell, GI
    DIABETES, 1997, 46 (10) : 1648 - 1651
  • [47] Beta-cell dysfunction rather than insulin resistance is the main factor in the development of post-renal transplantation diabetes mellitus
    Nam, JH
    Lee, HC
    Ahn, CW
    Kim, KR
    Huh, KB
    DIABETES, 2000, 49 : A72 - A73
  • [48] Mutation of hepatocyte nuclear factor-1β inhibits Pkhd1 gene expression and produces renal cysts in mice
    Hiesberger, T
    Bai, Y
    Shao, XL
    McNally, BT
    Sinclair, AM
    Tian, X
    Somlo, S
    Igarashi, P
    JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (06): : 814 - 825
  • [49] HEPATOCYTE NUCLEAR FACTOR-1B GENE DELETIONS AND CYSTIC RENAL DISEASE: AN UNDER RECOGNIZED CAUSE OF RENAL DISEASE IN ADULTS?
    Hutton, H.
    Polkinghorne, K.
    NEPHROLOGY, 2011, 16 : 38 - 39
  • [50] A low renal threshold for glucose in diabetic patients with a mutation in the hepatocyte nuclear factor-1α (HNF-1α) gene
    Menzel, R
    Kaisaki, PJ
    Rjasanowski, I
    Heinke, P
    Kerner, W
    Menzel, S
    DIABETIC MEDICINE, 1998, 15 (10) : 816 - 820
12345