DNA methylome: Unveiling your biological age

被引：6
|
作者：
Li, Ming [1 ]
Liu, Wensu [1 ]
Yuan, Tingting [1 ]
Bai, Ruijun [1 ]
Liu, Guang-Hui [1 ,2 ,3 ]
Zhang, Weizhou [4 ]
Qu, Jing [1 ]
机构：
[1] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
[3] Beijing Inst Brain Disorders, Beijing 100069, Peoples R China
[4] Univ Iowa, Dept Pathol, Carver Coll Med, Iowa City, IA 52242 USA
来源：
PROTEIN & CELL | 2013年 / 4卷 / 10期
关键词：
STEM-CELLS; TELOMERES; IPSCS;
D O I：
10.1007/s13238-013-3913-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy. This progress enlightens us in many aspects particularly in applying this novel set of bio-markers on studying the mechanism of aging rate using adult tissue-specific stem cells, building up a potential quantitative model to explore the mechanism for other epigenetic factors like non-coding RNA, and understanding the principle and mechanism of 3D chromatin structure in epigenetic modulation.
引用
收藏
页码：723 / 725
页数：3
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