Development of the Paris Definition of Early Crohn's Disease for Disease-Modification Trials: Results of an International Expert Opinion Process

被引：81

作者：

Peyrin-Biroulet, Laurent ^{[1
,2
]}

Billioud, Vincent ^{[1
,2
]}

D'Haens, Geert ^{[3
]}

Panaccione, Remo ^{[4
]}

Feagan, Brian ^{[5
,6
]}

Panes, Julian ^{[7
]}

Danese, Silvio ^{[8
]}

Schreiber, Stefan ^{[9
]}

Ogata, Haruhiko ^{[10
]}

Hibi, Toshifumi ^{[10
]}

Higgins, Peter D. R. ^{[11
]}

Beaugerie, Laurent ^{[12
,13
]}

Chowers, Yehuda ^{[14
,15
]}

Louis, Edouard ^{[16
,17
]}

Steinwurz, Flavio ^{[18
]}

Reinisch, Walter ^{[19
]}

Rutgeerts, Paul ^{[20
]}

Colombel, Jean-Frederic ^{[21
]}

Travis, Simon ^{[22
]}

Sandborn, William J. ^{[23
]}

机构：

[1] Univ Henri Poincare 1, INSERM, U954, F-54511 Vandoeuvre Les Nancy, France

[2] Univ Henri Poincare 1, Univ Hosp Nancy, Dept Hepatogastroenterol, F-54511 Vandoeuvre Les Nancy, France

[3] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands

[4] Univ Calgary, Inflammatory Bowel Dis Clin, Calgary, AB, Canada

[5] Robarts Res Inst, London, ON N6A 5C1, Canada

[6] Univ Western Ontario, London, ON, Canada

[7] CIBERehd, IDIBAPS, Hosp Clin, Dept Gastroenterol, Barcelona, Spain

[8] Ist Clin Humanitas, Dept Gastroenterol, Rozzano, Italy

[9] Univ Kiel, Univ Hosp Kiel, Kiel, Germany

[10] Keio Univ, Sch Med, Tokyo, Japan

[11] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[12] Univ Paris, Univ Paris 06, F-75252 Paris, France

[13] Univ Paris, Hop St Antoine, AP HP, Dept Gastroenterol, F-75252 Paris, France

[14] Dept Gastroenterol, Haifa, Israel

[15] Technion Israel Inst Technol, Bruce Rappaport Sch Med, Haifa, Israel

[16] Univ Liege, CHU Liege, Dept Gastroenterol, Liege, Belgium

[17] Univ Liege, GIGA Res, Liege, Belgium

[18] Hosp Israelita Albert Einstein, Sao Paulo, Brazil

[19] Med Univ Vienna, Div Gastroenterol & Hepatol, Dept Internal Med 3, Vienna, Austria

[20] Univ Hosp Gasthuisberg, B-3000 Louvain, Belgium

[21] Univ Lille Nord France, CHU Lille, Lille, France

[22] John Radcliffe Hosp, Translat Gastroenterol Unit, Oxford OX3 9DU, England

[23] Univ Calif San Diego, La Jolla, CA 92093 USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2012年 / 107卷 / 12期

关键词：

EARLY MULTIPLE-SCLEROSIS; INTESTINAL FIBROSIS; BOWEL OBSTRUCTION; NATURAL-HISTORY; RISK-FACTORS; COMPLICATIONS; REMISSION; THERAPY; CLASSIFICATION; INFLAMMATION;

D O I：

10.1038/ajg.2012.117

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD. Am J Gastroenterol 2012;107:1770-1776; doi:10.1038/ajg.2012.117

引用

页码：1770 / 1776

页数：7

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