Development of the Paris Definition of Early Crohn's Disease for Disease-Modification Trials: Results of an International Expert Opinion Process

被引：81

作者：

Peyrin-Biroulet, Laurent ^{[1
,2
]}

Billioud, Vincent ^{[1
,2
]}

D'Haens, Geert ^{[3
]}

Panaccione, Remo ^{[4
]}

Feagan, Brian ^{[5
,6
]}

Panes, Julian ^{[7
]}

Danese, Silvio ^{[8
]}

Schreiber, Stefan ^{[9
]}

Ogata, Haruhiko ^{[10
]}

Hibi, Toshifumi ^{[10
]}

Higgins, Peter D. R. ^{[11
]}

Beaugerie, Laurent ^{[12
,13
]}

Chowers, Yehuda ^{[14
,15
]}

Louis, Edouard ^{[16
,17
]}

Steinwurz, Flavio ^{[18
]}

Reinisch, Walter ^{[19
]}

Rutgeerts, Paul ^{[20
]}

Colombel, Jean-Frederic ^{[21
]}

Travis, Simon ^{[22
]}

Sandborn, William J. ^{[23
]}

机构：

[1] Univ Henri Poincare 1, INSERM, U954, F-54511 Vandoeuvre Les Nancy, France

[2] Univ Henri Poincare 1, Univ Hosp Nancy, Dept Hepatogastroenterol, F-54511 Vandoeuvre Les Nancy, France

[3] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands

[4] Univ Calgary, Inflammatory Bowel Dis Clin, Calgary, AB, Canada

[5] Robarts Res Inst, London, ON N6A 5C1, Canada

[6] Univ Western Ontario, London, ON, Canada

[7] CIBERehd, IDIBAPS, Hosp Clin, Dept Gastroenterol, Barcelona, Spain

[8] Ist Clin Humanitas, Dept Gastroenterol, Rozzano, Italy

[9] Univ Kiel, Univ Hosp Kiel, Kiel, Germany

[10] Keio Univ, Sch Med, Tokyo, Japan

[11] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[12] Univ Paris, Univ Paris 06, F-75252 Paris, France

[13] Univ Paris, Hop St Antoine, AP HP, Dept Gastroenterol, F-75252 Paris, France

[14] Dept Gastroenterol, Haifa, Israel

[15] Technion Israel Inst Technol, Bruce Rappaport Sch Med, Haifa, Israel

[16] Univ Liege, CHU Liege, Dept Gastroenterol, Liege, Belgium

[17] Univ Liege, GIGA Res, Liege, Belgium

[18] Hosp Israelita Albert Einstein, Sao Paulo, Brazil

[19] Med Univ Vienna, Div Gastroenterol & Hepatol, Dept Internal Med 3, Vienna, Austria

[20] Univ Hosp Gasthuisberg, B-3000 Louvain, Belgium

[21] Univ Lille Nord France, CHU Lille, Lille, France

[22] John Radcliffe Hosp, Translat Gastroenterol Unit, Oxford OX3 9DU, England

[23] Univ Calif San Diego, La Jolla, CA 92093 USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2012年 / 107卷 / 12期

关键词：

EARLY MULTIPLE-SCLEROSIS; INTESTINAL FIBROSIS; BOWEL OBSTRUCTION; NATURAL-HISTORY; RISK-FACTORS; COMPLICATIONS; REMISSION; THERAPY; CLASSIFICATION; INFLAMMATION;

D O I：

10.1038/ajg.2012.117

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD. Am J Gastroenterol 2012;107:1770-1776; doi:10.1038/ajg.2012.117

引用

页码：1770 / 1776

页数：7

共 50 条

[31] Twelve Years of Drug Prioritization to Help Accelerate Disease Modification Trials in Parkinson's Disease: The International Linked Clinical Trials Initiative
Wyse, Richard K.
Isaacs, Tom
Barker, Roger A.
Cookson, Mark R.
Dawson, Ted M.
Devos, David
Dexter, David T.
Duffen, Joy
Federoff, Howard
Fiske, Brian
Foltynie, Thomas
Fox, Susan
Greenamyre, J. Timothy
Kieburtz, Karl
Kordower, Jeffrey H.
Krainc, Dimitri
Matthews, Helen
Moore, Darren J.
Mursaleen, Leah
Schwarzschild, Michael A.
Stott, Simon R. W.
Sulzer, David
Svenningsson, Per
Tanner, Caroline M.
Carroll, Camille
Simon, David K.
Brundin, Patrik
JOURNAL OF PARKINSONS DISEASE, 2024, 14 (04) : 657 - 666
[32] Relationship between microbiota and development of early postoperative Crohn's disease recurrence
Machiels, K.
Pascal, V.
Sabino, J.
Santiago, A.
Campos, D.
Wolthuis, A.
van Overstraeten, A. De Buck
D'Hoore, A.
Van Assche, G.
Ferrante, M.
Rutgeerts, P.
Manichanh, C.
Vermeire, S.
JOURNAL OF CROHNS & COLITIS, 2017, 11 : S53 - S53
[33] Appropriate therapy for fistulizing and fibrostenotic Crohn's disease: Results of a multidisciplinary expert panel - EPACT II
Felley, Christian
Vader, John-Paul
Juillerat, Pascal
Pittet, Valerie
O'Morain, Colm
Panis, Yves
Vucelic, Boris
Gonvers, Jean-Jacques
Mottet, Christian
Froehlich, Florian
Michetti, Pierre
JOURNAL OF CROHNS & COLITIS, 2009, 3 (04): : 250 - 256
[34] Crohn's disease prognosis and early immunomodulator therapy: Results from the CONNECT study
Kim, Bun
Cheon, Jae Hee
Moon, Hyun Jin
Park, Yi Rang
Ye, Byong Duk
Yang, Suk-Kyun
Seo, Geom Seog
Jang, Byung Ik
Kim, You Sun
Kim, Joo Sung
Han, Dong Soo
Kim, Young-Ho
Kim, Won Ho
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2016, 31 (01) : 126 - 132
[35] Is there a standardized practice for the development of international ulcerative colitis and Crohn's disease treatment guidelines?
Goldowsky, Alexander
Sen, Rohan
Hoffman, Gila
Feuerstein, Joseph D.
GASTROENTEROLOGY REPORT, 2021, 9 (05): : 408 - 417
[36] Surgical treatment of jejuno-ileal Crohn's disease. Results from the The JejUno Ileal Crohn's disEase (JUICE) international, multicentric, observational study
Baldi, C.
Mineccia, M.
Ferrero, A.
Di Benedetto, M.
Spinelli, A.
Scarpa, M.
Angriman, I.
Cricri, M.
Luglio, G.
Colombo, F.
Danelli, P.
Bislenghi, G.
D'Hoore, A.
Nasasra, A.
Warusavitarne, J.
Manzo, C. A.
Celentano, V.
Marti-Gallostra, M.
Basany, E. Espin
Schena, C. A.
Pellino, G.
De Angelis, N.
Rottoli, M.
Poggioli, G.
Sampietro, G. M.
JOURNAL OF CROHNS & COLITIS, 2024, 18 : I1094 - I1094
[37] Identifying Outcomes in Clinical Trials of Fistulizing Crohn's Disease for the Development of a Core Outcome Set
Ma, Christopher
Parker, Claire E.
Nguyen, Tran M.
Khanna, Reena
Feagan, Brian G.
Jairath, Vipul
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2019, 17 (09) : 1904 - 1908
[38] Editorial: an expert consensus to standardise the assessment of histological disease activity in Crohn's disease clinical trials-a missing link. Authors' reply
Jairath, Vipul
Almradi, Ahmed
Pai, Rish K.
Ma, Christopher
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2021, 53 (08) : 952 - 952
[39] Management of Patients With Crohn's Disease and Ulcerative Colitis During the Coronavirus Disease-2019 Pandemic: Results of an International Meeting
Rubin, David T.
Abreu, Maria T.
Rai, Victoria
Siegel, Corey A.
GASTROENTEROLOGY, 2020, 159 (01) : 6 - +
[40] Heterogeneity in the Endoscopic Management of Crohn's Disease Associated Strictures: Results From an International Inflammatory Bowel Disease Specialist Survey
Bettenworth, Dominik
Lopez, Rocio
Hindryckx, Pieter
Levesque, Barrett G.
Rieder, Florian
GASTROENTEROLOGY, 2015, 148 (04) : S459 - S460

← 1 2 3 4 5 →